KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection. KREMEN1 is also essential for infection by a phylogenetic and pathogenic related group of Human type A Enteroviruses (EV-As). Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type, and Hand, Foot, And Mouth Disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 μg | 5 days | $ 600.00 | |
1 mg | 5 days | $ 4,570.00 |
Description | KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection. KREMEN1 is also essential for infection by a phylogenetic and pathogenic related group of Human type A Enteroviruses (EV-As). Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type, and Hand, Foot, And Mouth Disease. |
Species | Human |
Expression System | HEK293 |
Tag | His |
Accession Number | Q96MU8-2 |
Synonyms | KREMEN, KRM1, kringle containing transmembrane protein 1 |
Construction | A DNA sequence encoding the human KREMEN1 (NP_114434.3) (Met1-Thr394) was expressed with a polyhistidine tag at the C-terminus. |
Protein Purity | > 95 % as determined by SDS-PAGE |
Molecular Weight | Approxiamtely 42.6 kDa |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Reconstitution | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
Stability & Storage |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection. KREMEN1 is also essential for infection by a phylogenetic and pathogenic related group of Human type A Enteroviruses (EV-As). Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type, and Hand, Foot, And Mouth Disease. |
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Kremen-1 Protein, Human, Recombinant (His) KRM 1 KREMEN KRM1 kringle containing transmembrane protein 1 KRM-1 recombinant recombinant-proteins proteins protein