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Anti-CD89 Antibody (5W394)
😃Good
Catalog No. TMAY-00791
Alias XXbac-BPG230H20.5, FcαRI, FCAR, FcalphaRI, Fc fragment of IgA receptor, CTB-61M7.2, CD89
Anti-CD89 Antibody (5W394) is a Mouse antibody targeting CD89. Anti-CD89 Antibody (5W394) can be used in ELISA,FCM.
Anti-CD89 Antibody (5W394)
Anti-CD89 Antibody (5W394)
😃Good
Catalog No. TMAY-00791Alias XXbac-BPG230H20.5, FcαRI, FCAR, FcalphaRI, Fc fragment of IgA receptor, CTB-61M7.2, CD89
Anti-CD89 Antibody (5W394) is a Mouse antibody targeting CD89. Anti-CD89 Antibody (5W394) can be used in ELISA,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA, FCM Reactivity: Human |
| Alias | XXbac-BPG230H20.5, FcαRI, FCAR, FcalphaRI, Fc fragment of IgA receptor, CTB-61M7.2, CD89 |
| Ig Type | Mouse IgG1 |
| Clone | 5W394 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD89 expression on Human blood granulocytes. Cells were stained with purified anti-Human CD89, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of viable granuolcytes. |
| Application | ELISA,FCM |
| Recommended Dose | ELISA: 1:1000-1:2000; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD89 / FCAR (rh CD89; TMPY-00716; NP_001991.1; Met 1-Asn 227). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation. |
| Conjucates | Unconjugated |
| Others Formats | APC/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Protein: Human CD89 protein (TMPY-00716) |
| Antigen Species | Human |
| Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules, Fc Receptors |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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