keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), functions as an inhibitor of both Cathepsin B (Cat-B) and Cathepsin L (Cat-L), and is utilized in research pertaining to the aggressiveness of cancer [1] [2].
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Description | Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), functions as an inhibitor of both Cathepsin B (Cat-B) and Cathepsin L (Cat-L), and is utilized in research pertaining to the aggressiveness of cancer [1] [2]. |
In vitro | Ac-VLPE-FMK (2 μM) significantly affects the cleavage of the probe Ac-PLVQ-AMC by recombinant human CtsB and L [1]. Ac-VLPE-FMK (30 min) inhibits fluorescence resulting from the cleavage of substrate Ac-PLVQ-AMC in 769-p and A498 cells [1]. Ac-VLPE-FMK (2.5-250 μM; 24-72 h) does not affect the viability of renal cancer cells but alters cell migration rate, adhesion, colony formation, and marker expression [1]. |
Synonyms | Ac-Val-Leu-Pro-Glu(OMe)-CH2F |
Molecular Weight | 528.61 |
Formula | C25H41FN4O7 |
CAS No. | 2679825-27-3 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Ac-VLPE-FMK 2679825-27-3 Ac-Val-Leu-Pro-Glu(OMe)-CH2F inhibitor inhibit