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Anti-SARS-CoV-2 (2019-nCoV) Spike Neutralizing Antibody (7D603)
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Catalog No. TMAB-01660
Alias Surface glycoprotein, SPIKE_SARS2, Spike protein S1, Spike protein RBD, Spike glycoprotein, SARS-CoV-2 spike protein, 2019-nCOV Spike protein
Anti-SARS-CoV-2 (2019-nCoV) Spike Neutralizing Antibody (7D603) is a Mouse antibody targeting SARS-CoV-2 (2019-nCoV) Spike Neutralizing. Anti-SARS-CoV-2 (2019-nCoV) Spike Neutralizing Antibody (7D603) can be used in ELISA.
Anti-SARS-CoV-2 (2019-nCoV) Spike Neutralizing Antibody (7D603)
Anti-SARS-CoV-2 (2019-nCoV) Spike Neutralizing Antibody (7D603)
😃Good
Catalog No. TMAB-01660Alias Surface glycoprotein, SPIKE_SARS2, Spike protein S1, Spike protein RBD, Spike glycoprotein, SARS-CoV-2 spike protein, 2019-nCOV Spike protein
Anti-SARS-CoV-2 (2019-nCoV) Spike Neutralizing Antibody (7D603) is a Mouse antibody targeting SARS-CoV-2 (2019-nCoV) Spike Neutralizing. Anti-SARS-CoV-2 (2019-nCoV) Spike Neutralizing Antibody (7D603) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $679 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-SARS-CoV-2 (2019-nCoV) Spike Neutralizing Antibody (7D603) is a Mouse antibody targeting SARS-CoV-2 (2019-nCoV) Spike Neutralizing. Anti-SARS-CoV-2 (2019-nCoV) Spike Neutralizing Antibody (7D603) can be used in ELISA. |
| Synonyms | Surface glycoprotein, SPIKE_SARS2, Spike protein S1, Spike protein RBD, Spike glycoprotein, SARS-CoV-2 spike protein, 2019-nCOV Spike protein |
| Ig Type | IgG1 |
| Clone | 7D603 |
| Reactivity | Virus |
| Verified Activity | 1. The ACE2-coated plate is incubated with SARS-CoV-2 Spike RBD-HRP (WT) and Anti-SARS-CoV-2 Spike RBD Neutralizing antibody. Percent inhibition is calculated based on the OD value by inhibiting RBD: ACE2 interaction. 2. Direct ELISA was used to detect the binding ability of anti-RBD monoclonal antibody to RBD domain proteins of different SARS-CoV-2 Mutant Strains. Immobilized SARS-CoV-2 RBD proteins, at 2 μg/ml (100ul/Well) can bind Anti-RBD monoclonal antibody-HRP at 1 μg/ml (100ul/Well). |
| Application | |
| Recommended Dose | ELISA: 1:5000-10000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Virion membrane ; Single-pass type I membrane protein ; Host endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein ; Host cell membrane ; Single-pass type I membrane protein ;Note: Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion. |
| Tissue Specificity | The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.Specific enzymatic cleavages in vivo yield mature proteins. The precurssor is processed into S1 and S2 by host cell furin or another cellular protease t |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M PBS (pH7.4). |
| Concentration | Lot Dependent |
| Research Background | The SARS-CoV-2 spike (S) protein is the target of vaccine design efforts to end the COVID-19 pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic, and are now the dominant form worldwide. Here, we analyze the D614G mutation in the context of a soluble S ectodomain construct. |
| Immunogen | Recombinant Protein: SARS-CoV-2 Spike S1 Protein |
| Gene Name | S |
| Protein Name | Spike glycoprotein |
| Biology Area | SARS Coronavirus |
| Function | attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. |
| Molecular Weight | Theoretical: 140 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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