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TargetMol | Tags Membrane transporter/Ion channel
TargetMol | Tags Metabolism

Calcium Channel

A calcium channel is an ion channel which shows selective permeability to calcium ions. It is sometimes synonymous with voltage-gated calcium channel, although there are also ligand-gated calcium channels.

  • Thapsigargin
    TQ030267526-95-8
    Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking the ability of cells to pump calcium into the sarcoplasmic and endoplasmic reticulum.
    • $82
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  • Ionomycin
    T728556092-81-0
    Ionomycin is an calcium ionophore and an antibiotic that binds calcium ions (Ca2+). It is produced by the bacterium Streptomyces conglobatus.It is used in research to raise the intracellular calcium level (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. Ionomycin promotes apoptosis and induces the activation of protein kinase C (PKC).
    • $196
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  • 2,5-Di-tert-butylhydroquinone
    T754088-58-4
    2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.
    • $29
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  • Levetiracetam
    T0192102767-28-2
    Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and to rare cases of clinically apparent drug induced liver disease.
    • $50
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  • Nimodipine
    T034366085-59-4
    Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
    • $40
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    TargetMol | Citations Cited
  • JTV-519 fumarate
    T378071883549-36-7
    JTV-519 fumarate (K201 fumarate) is a SERCA blocker and partial agonist at the ryanodine receptor with antiarrhythmic and cardioprotective effects, improves sarcoplasmic reticulum calcium leakage, and may be useful in the study of anxiety disorders.
    • $146
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  • Nisoldipine
    T016363675-72-9
    Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
    • $41
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    TargetMol | Citations Cited
  • L-Ascorbic acid
    T092850-81-7
    L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.
    • $42
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  • L-Phenylalanine
    T337763-91-2
    L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.
    • $42
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  • Levamlodipine besylate
    T4284150566-71-5
    Levamlodipine besylate ((S)-Amlodipine Besylate (103129-82-4(free base))) , also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and anti-anginal medication. Levamlodipine besylate belongs to the dihydropyridine group of calcium channel blockers. The names S-amlodipine and levamlodipine may be used interchangeably as both substances are the same, however, with differing nomenclature. As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity.
    • $35
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  • 1,2,4-Trihydroxybenzene
    T37705533-73-3
    1,2,4-Trihydroxybenzene (Benzene-1,2,4-triol) is a by-product of coffee bean roasting and is found in mouse, arabica coffee.1,2,4-Trihydroxybenzene is a benzotriol that increases Ca2+ concentration in rat thymic lymphocytes.
    • $42
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  • Lanthanum(III) chloride heptahydrate
    T2235310025-84-0
    Lanthanum(III) chloride is an inorganic compound which used in biochemical research to block the activity of divalent cation channels, especially calcium channels.
    • $40
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  • Ethyl cinnamate
    TN1624103-36-6
    Ethyl cinnamate has antifungal, and vasorelaxant effects. Ethyl cinnamate can lead to the damage of cell membrane system and metabolic disorder through inducing lipid peroxidation via initiating ROS overproduction. Ethyl cinnamate can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dependent manner, with respective IC50 values of 0.30 mM and 0.38 mM.
    • $30
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  • PD 0299685
    T68125L313651-33-1In house
    PD 0299685 is a potent α2δ ligand of the Ca2+ channel for the treatment of interstitial cystitis.
    • $195
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  • Clopimozide
    T2526353179-12-7In house
    Clopimozide (R-29764) acts as a calcium channel antagonist and inhibits [3H] nilandipine binding.Clopimozide is a novel and orally available long-acting antischizophrenic psychostatic compound.
    • $143
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  • Darodipine
    T1505372803-02-2
    Darodipine (PY-108068) is a dihydropyridine type Ca+2 antagonist.
    • $55
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  • MDK-4025
    T1976566774-02-5
    MDK-4025 is an inhibitor of the high voltage-activated (HVA) Ca2+ current in pyramidal neurons.
    • $133
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  • Ser-Ala-alloresact acetate
    T76373L
    Ser-Ala-alloresact acetate is a sperm-activating peptide (SAP) that is released by marine invertebrate eggs and plays an important role in fertilization.
    • $98
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  • Crobenetine
    T69795221019-25-6In house
    Crobenetine (BIII 890 CL) Free Base is a selective NaV channel blocker that eliminates VTD-induced [Ca2+] elevation.
    • $310
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  • Tamolarizine
    T3478293035-32-6In house
    Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.
    • $143
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  • SB-237376 HCl
    T28686179258-62-9In house
    SB-237376 HCl (SB-237376 hydrochloride) is a calcium and potassium channel antagonist used in the treatment of cardiac arrhythmias.
    • $293
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  • Terodiline
    T6053615793-40-5In house
    Terodiline is a seconal amine with anticholinergic and calcium antagonistic properties that blocks the hERG current (IC50: 375 nM).Terodiline is cardiotoxic and has been used in the study of disorders caused by urethral muscle instability.
    • $293 TargetMol
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  • FPL-62129
    T2735795445-79-7In house
    FPL-62129 is a calcium channel antagonist and a novel angiotensin-converting enzyme inhibitor with vasodilator activity for the study of cardiovascular disease.
    • $293 TargetMol
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  • Sesamodil
    T28759116476-13-2In house
    Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.
    • $693
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  • McN5691
    T1197999254-95-2In house
    McN5691 (RWJ26240) is a voltage-dependent calcium channel blocker with antihypertensive activity that can be used in the study of diseases caused by vascular smooth muscle abnormalities.
    • $293 TargetMol
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  • K201
    T242391038410-88-6In house
    K201 (JTV-519) is a Ca2+-dependent blocker and prevents abnormal Ca(2+) leak from the sarcoplasmic reticulum in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors.
    • $55
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  • Fasudil
    T1606103745-39-7
    Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
    • $33
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  • TTA-A8
    T719901146395-46-1
    TTA-A8 is an antagonist of T-type calcium channel.
    • $397
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  • Jamaicin
    T2373524211-36-7
    Jamaicin (AnCoA4), an isoflavone derived from the chickweed plant, is an inhibitor of the STIM1-Orai1 channel that blocks calcium influx, reduces its interaction with STIM1, and inhibits T-cell activation.
    • $127
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  • Calcium channel-modulator-1
    T10101136941-70-3In house
    Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction.
    • $166
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  • Diproteverine HCl
    T6885369373-88-2In house
    Diproteverine HCl is a novel calcium antagonist with antianginal properties, antispasmodic and vasoactive.
    • $195
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  • Cis-22a
    T412331819366-84-1In house
    Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.
    • $129
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  • Temiverine hydrochloride
    T13118136529-33-4In house
    Temiverine hydrochloride is a potential calcium channel antagonist with anticholinergic effects that inhibits some of the functions of atropine.
    • $293 TargetMol
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  • Upacicalcet
    T290671333218-50-0In house
    Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-sensitive receptors, thereby lowering blood levels of PTH.Upacicalcet is an orthosteric modulator of calcium-sensitive receptors and prevents adenine-induced secondary vascular calcification and bone disease in a rat model of adenine-induced secondary hyperparathyroidism.
    • $110
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  • CALP3 acetate(261969-05-5 free base)
    TP1911L
    CALP3 acetate is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 acetate can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps.
    • $137
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  • Iganidipine
    T15553119687-33-1
    Iganidipine(NKY 722) is a new water-soluble Ca2+ antagonist with antihypertensive activity for research and neurological related diseases.
    • $700
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  • Gallopamil
    T1135316662-47-8In house
    Gallopamil (Methoxyverapamil) inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist.
    • $32
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  • SB-237376
    T28686L179258-59-4In house
    SB-237376 is a calcium and potassium channel antagonist used to treat cardiac arrhythmias.
    • $195
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  • Levosemotiadil
    T25701116476-16-5In house
    Levosemotiadil(SA 3212) is a novel calcium antagonist and a very potent inhibitor of low-density lipoprotein oxidation.Levosemotiadil may be used to prevent lethal cardiac arrhythmias.
    • $693
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  • CP-060
    T10874180090-15-7In house
    CP-060 is a potent Ca2+ antagonist and inhibits Ca2+ overload with antioxidant and cardioprotective activities.
    • $597
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  • KT-362 free base
    T7358793392-97-3In house
    KT-362 is a calcium channel blocker with antihypertensive properties that can be used in the study of cardiovascular disease.
    • $195
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  • Vesnarinone HCl
    T3465L In house
    Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new positive inotropic compound that enhances myocardial contractility and can be be used in heart failure studies.
    • $50
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  • Cronidipine
    T27087113759-50-5In house
    Cronidipine (LF 20254), a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia.
    • $146
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  • AY 77
    T411901835734-92-3In house
    AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM). AY 77 can promote migration of human breast cancer cells in vitro.
    • $686
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  • Lifarizine
    T27830119514-66-8In house
    Lifarizine (RS-87476), a calcium-sodium channel antagonist, shows neuroprotective activity in a simplified rat survival model of double vessel occlusion.
    • $146
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  • Ticolubant
    T28974154413-61-3In house
    Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inflammatory activity in a mouse model of skin inflammation.
    • $210
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  • HA-1004 dihydrochloride
    T868192564-34-6
    HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
    • $370
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  • Vatanidipine
    T24932116308-55-5In house
    Vatanidipine (AE0047) is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.A slow-onset and long-lasting hypotensive action was observed in various experimental hypertensive models.
    • $197
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  • EMD57033
    T25372147527-31-9In house
    EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction.
    • $350
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  • Tiapamil hydrochloride
    T1315457010-32-9In house
    Tiapamil hydrochloride (Ro 11-1781 hydrochloride) is a calcium channel blocker with antihypertensive activity and may be used in the study of angina and cardiovascular disease.
    • $293 TargetMol
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