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KN1022
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Catalog No. T60110Cas No. 205255-11-4
KN1022 is an inhibitor of phosphorylation of platelet-derived growth factor (PDGF) receptor with IC50 of 0.26 μM.
KN1022
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Purity: 99.68%
Catalog No. T60110Cas No. 205255-11-4
KN1022 is an inhibitor of phosphorylation of platelet-derived growth factor (PDGF) receptor with IC50 of 0.26 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $70 | - | In Stock | |
| 5 mg | $161 | - | In Stock | |
| 10 mg | $236 | - | In Stock | |
| 25 mg | $355 | - | In Stock | |
| 50 mg | $497 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.68%
Appearance:Solid
Color:Yellow
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Product Introduction
KN1022 AI Summary
KN1022 inhibits the autophosphorylation of platelet-derived growth factor receptor beta (PDGFRβ) in CHO cells, with an IC50 value of 700.0 nM, as measured using a two-site enzyme-linked immunosorbent assay (ELISA). The compound exhibits significant potency against multiple growth factor receptors and kinases, showing noteworthy inhibitory activity against PDGFRβ, Mast/stem cell growth factor receptor (c-Kit kinase), and PDGF-BB-induced proliferation of porcine aorta smooth muscle cells. It also demonstrates moderate inhibition of Flt3 kinase, but shows weaker or negligible activity against kinases such as the Epidermal growth factor receptor, Fibroblast growth factor receptor kinase, and Vascular endothelial growth factor receptor 2. Additionally, KN1022 has a lipophilicity (LogD) value of 3.22..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | KN1022 is an inhibitor of phosphorylation of platelet-derived growth factor (PDGF) receptor with IC50 of 0.26 μM. |
| Molecular Weight | 438.44 |
| Formula | C21H22N6O5 |
| Cas No. | 205255-11-4 |
| Smiles | O(C)C1=CC=2C(=NC=NC2C=C1OC)N3CCN(C(NC4=CC=C(N(=O)=O)C=C4)=O)CC3 |
| Relative Density. | 1.406 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (25.09 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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