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4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine

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Catalog No. T210517Cas No. 1203565-13-2

4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine is a brominated pyrrolopyridine-based scaffold designed for advanced medicinal chemistry and kinase inhibitor development. Its 7-azaindole (pyrrolopyridine) core serves as a purine bioisostere capable of occupying ATP-binding pockets across diverse kinases. The bromine substituent at the 5-position offers both electronic tuning and a versatile handle for cross-coupling reactions, enabling rapid SAR exploration. The 2-aminopyrimidine moiety further supports hinge-binding interactions, collectively making 4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine a valuable starting point for generating FGFR-targeted inhibitors and other kinase-directed therapeutics.

4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine

4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine

😃Good
Purity: 98.90%
Catalog No. T210517Cas No. 1203565-13-2
4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine is a brominated pyrrolopyridine-based scaffold designed for advanced medicinal chemistry and kinase inhibitor development. Its 7-azaindole (pyrrolopyridine) core serves as a purine bioisostere capable of occupying ATP-binding pockets across diverse kinases. The bromine substituent at the 5-position offers both electronic tuning and a versatile handle for cross-coupling reactions, enabling rapid SAR exploration. The 2-aminopyrimidine moiety further supports hinge-binding interactions, collectively making 4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine a valuable starting point for generating FGFR-targeted inhibitors and other kinase-directed therapeutics.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$195-In Stock
5 mg$483-In Stock
10 mg$691-In Stock
25 mg$1,080-In Stock
50 mg$1,490-In Stock
100 mg$1,960-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.90%
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Product Introduction

Bioactivity
Description
4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine is a brominated pyrrolopyridine-based scaffold designed for advanced medicinal chemistry and kinase inhibitor development. Its 7-azaindole (pyrrolopyridine) core serves as a purine bioisostere capable of occupying ATP-binding pockets across diverse kinases. The bromine substituent at the 5-position offers both electronic tuning and a versatile handle for cross-coupling reactions, enabling rapid SAR exploration. The 2-aminopyrimidine moiety further supports hinge-binding interactions, collectively making 4-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine a valuable starting point for generating FGFR-targeted inhibitors and other kinase-directed therapeutics.
Chemical Properties
Molecular Weight290.12
FormulaC11H8BrN5
Cas No.1203565-13-2
SmilesBrC=1C=NC=2NC=C(C=3N=C(N=CC3)N)C2C1
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

Nrf2IN4
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