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KWCN-41 (Synonyms: KWCN41, KWCN 41)

Name: KWCN-41
Brand: TargetMol
SKU: T74801
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T74801 Copy Product Info

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KWCN-41 is a potent and selective RIPK1 kinase inhibitor (IC50=88 nM) that specifically inhibits necrosis without affecting apoptosis and exhibits anti-inflammatory effects.

KWCN-41

Copy Product Info

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Catalog No. T74801

Synonyms KWCN41, KWCN 41

KWCN-41 is a potent and selective RIPK1 kinase inhibitor (IC50=88 nM) that specifically inhibits necrosis without affecting apoptosis and exhibits anti-inflammatory effects.

Cas No. 2913223-17-1

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$69	-	In Stock
5 mg	Preferential	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Brown

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Product Introduction

Bioactivity

Description	KWCN-41 is a potent and selective RIPK1 kinase inhibitor (IC50=88 nM) that specifically inhibits necrosis without affecting apoptosis and exhibits anti-inflammatory effects.
Targets&IC50	RIPK1:88 nM
In vitro	KWCN-41 (10/50/50 nM; 1 h) dose-dependently inhibited necrosis in L929 cells [1]. KWCN-41 (10/50/250 nM; 0.5/1.5/2.5 h) inhibited phosphorylation of RIPK1/3 and MLKL in L929 cells [1]. KWCN-41 (0-10 μM) dose-dependently inhibited TZ-induced necrosis in L929 cells and suppressed TSZ-induced necrosis in HT-29 and U937 cells [1].
In vivo	KWCN-41 (10/25/40 mg/kg; intraperitoneal injection; 72 hours) dose-dependently inhibited TNF-α-induced mouse mortality and improved survival rates [1].
Synonyms	KWCN41, KWCN 41

Chemical Properties

Molecular Weight	307.35
Formula	C₁₈H₁₇N₃O₂
Cas No.	2913223-17-1
Smiles	O=C(C1=CC=C(C=C1)C2=CC=3C=CC=NC3N2)N4CCOCC4

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (260.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2536 mL	16.2681 mL	32.5362 mL	162.6810 mL
5 mM	0.6507 mL	3.2536 mL	6.5072 mL	32.5362 mL
10 mM	0.3254 mL	1.6268 mL	3.2536 mL	16.2681 mL
20 mM	0.1627 mL	0.8134 mL	1.6268 mL	8.1340 mL
50 mM	0.0651 mL	0.3254 mL	0.6507 mL	3.2536 mL
100 mM	0.0325 mL	0.1627 mL	0.3254 mL	1.6268 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc