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KWCN-41
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Catalog No. T74801Cas No. 2913223-17-1
Alias KWCN41, KWCN 41
KWCN-41 is a potent and selective RIPK1 kinase inhibitor (IC50=88 nM) that specifically inhibits necrosis without affecting apoptosis and exhibits anti-inflammatory effects.
KWCN-41
😃Good
Catalog No. T74801Alias KWCN41, KWCN 41Cas No. 2913223-17-1
KWCN-41 is a potent and selective RIPK1 kinase inhibitor (IC50=88 nM) that specifically inhibits necrosis without affecting apoptosis and exhibits anti-inflammatory effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $173 | - | In Stock | |
| 5 mg | $433 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | KWCN-41 is a potent and selective RIPK1 kinase inhibitor (IC50=88 nM) that specifically inhibits necrosis without affecting apoptosis and exhibits anti-inflammatory effects. |
| Targets&IC50 | RIPK1:88 nM |
| In vitro | KWCN-41 (10/50/50 nM; 1 h) dose-dependently inhibited necrosis in L929 cells [1]. KWCN-41 (10/50/250 nM; 0.5/1.5/2.5 h) inhibited phosphorylation of RIPK1/3 and MLKL in L929 cells [1]. KWCN-41 (0-10 μM) dose-dependently inhibited TZ-induced necrosis in L929 cells and suppressed TSZ-induced necrosis in HT-29 and U937 cells [1]. |
| In vivo | KWCN-41 (10/25/40 mg/kg; intraperitoneal injection; 72 hours) dose-dependently inhibited TNF-α-induced mouse mortality and improved survival rates [1]. |
| Synonyms | KWCN41, KWCN 41 |
| Molecular Weight | 307.35 |
| Formula | C18H17N3O2 |
| Cas No. | 2913223-17-1 |
| Smiles | O=C(C1=CC=C(C=C1)C2=CC=3C=CC=NC3N2)N4CCOCC4 |
| Color | Brown |
| Appearance | Solid |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (260.29 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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