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Eperezolid

Name: Eperezolid
Brand: TargetMol
SKU: T15237
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15237Cas No. 165800-04-4

Alias PNU-100592

Eperezolid (PNU-100592) is an oxazolidinone antibacterial agent. Eperezolid showed well in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci(MIC90= 1-4 mg/ml).

Eperezolid

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Purity: 96.18%

Catalog No. T15237Alias PNU-100592Cas No. 165800-04-4

Eperezolid (PNU-100592) is an oxazolidinone antibacterial agent. Eperezolid showed well in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci(MIC90= 1-4 mg/ml).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
2 mg	$127	In Stock	In Stock
5 mg	$213	In Stock	In Stock
10 mg	$297	In Stock	In Stock
25 mg	$488	In Stock	In Stock
50 mg	$687	In Stock	In Stock
100 mg	$928	In Stock	In Stock
500 mg	$1,850	-	In Stock
1 mL x 10 mM (in DMSO)	$235	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:96.18%

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COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Eperezolid (PNU-100592) is an oxazolidinone antibacterial agent. Eperezolid showed well in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci(MIC90= 1-4 mg/ml).
In vitro	The specific binding of eperezolid is dose-dependent and is proportional to the ribosome concentrations. The binding of eperezolid to the ribosome is competitively inhibited by chloramphenicol and lincomycin. However, unlike chloramphenicol and lincomycin, eperezolid does not inhibit the puromycin reaction, indicating that the oxazolidinones have no effect on peptidyl transferase [2]. Antibiotic Eperezolid binds specifically to the 50S ribosomal subunit of Escherichia coli. eperezolid was found to bind only to the 50S subunit, with similar affinity as to the 70S ribosome, and to have no affinity for the 30S subunit [3].
Synonyms	PNU-100592

Chemical Properties

Molecular Weight	394.4
Formula	C₁₈H₂₃FN₄O₅
Cas No.	165800-04-4
Smiles	CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCN(CC2)C(=O)CO)c(F)c1
Relative Density.	1.370 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (101.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5355 mL	12.6775 mL	25.3550 mL	126.7748 mL
5 mM	0.5071 mL	2.5355 mL	5.0710 mL	25.3550 mL
10 mM	0.2535 mL	1.2677 mL	2.5355 mL	12.6775 mL
20 mM	0.1268 mL	0.6339 mL	1.2677 mL	6.3387 mL
50 mM	0.0507 mL	0.2535 mL	0.5071 mL	2.5355 mL
100 mM	0.0254 mL	0.1268 mL	0.2535 mL	1.2677 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc