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SR2211

Name: SR2211
Brand: TargetMol
SKU: T16929
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16929Cas No. 1359164-11-6

SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).

SR2211

🥰Excellent

Purity: 98.75%

Catalog No. T16929Cas No. 1359164-11-6

SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$97	In Stock
10 mg	$189	In Stock
25 mg	$289	In Stock
50 mg	$396	In Stock
100 mg	$562	In Stock
500 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Batch Information

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Purity:98.75%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).
Targets&IC50	RORγ:105 nM(ki), RORγ:320 nM
In vitro	In EL-4 cells, SR2211 inhibits the expression of IL-23 receptor and IL-17 intracellular staining[1].

Chemical Properties

Molecular Weight	527.48
Formula	C₂₆H₂₄F₇N₃O
Cas No.	1359164-11-6
Smiles	OC(c1ccc(c(F)c1)-c1ccc(CN2CCN(Cc3ccncc3)CC2)cc1)(C(F)(F)F)C(F)(F)F
Relative Density.	1.358 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (170.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8958 mL	9.4790 mL	18.9581 mL	94.7903 mL
5 mM	0.3792 mL	1.8958 mL	3.7916 mL	18.9581 mL
10 mM	0.1896 mL	0.9479 mL	1.8958 mL	9.4790 mL
20 mM	0.0948 mL	0.4740 mL	0.9479 mL	4.7395 mL
50 mM	0.0379 mL	0.1896 mL	0.3792 mL	1.8958 mL
100 mM	0.0190 mL	0.0948 mL	0.1896 mL	0.9479 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc