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N-Me-N-bis(PEG4-acid) is a PEG-based linker used in PROTACs to join two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $41 | 5 days | |
10 mg | $57 | 5 days |
Description | N-Me-N-bis(PEG4-acid) is a PEG-based linker used in PROTACs to join two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells. |
In vitro | PROTACs consist of two distinct ligands joined by a linker: one ligand targets an E3 ubiquitin ligase, while the other targets the desired protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Molecular Weight | 527.6 |
Formula | C23H45NO12 |
Cas No. | 2055014-77-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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