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Zongertinib

🥰Excellent
Catalog No. T69534Cas No. 2728667-27-2
Alias BI 764532, BI 1810631

Zongertinib is a human HER2-selective tyrosine kinase inhibitor, a novel TK that is highly selective for covalent binding to the HER2 tyrosine kinase domain (TKD).Zongertinib exhibits antitumor activity with inhibitory effects on pHER2 and EGF.

Zongertinib

Zongertinib

🥰Excellent
Purity: 98.24%
Catalog No. T69534Alias BI 764532, BI 1810631Cas No. 2728667-27-2
Zongertinib is a human HER2-selective tyrosine kinase inhibitor, a novel TK that is highly selective for covalent binding to the HER2 tyrosine kinase domain (TKD).Zongertinib exhibits antitumor activity with inhibitory effects on pHER2 and EGF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$64In StockIn Stock
5 mg$156In StockIn Stock
10 mg$247In StockIn Stock
25 mg$413In StockIn Stock
50 mg$579In StockIn Stock
100 mg$787-In Stock
1 mL x 10 mM (in DMSO)$183In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.24%
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Product Introduction

Bioactivity
Description
Zongertinib is a human HER2-selective tyrosine kinase inhibitor, a novel TK that is highly selective for covalent binding to the HER2 tyrosine kinase domain (TKD).Zongertinib exhibits antitumor activity with inhibitory effects on pHER2 and EGF.
Targets&IC50
NCI-H-2170 cells (HER2 WT Amp):6 nM, BaF3 HER2 YVMA cells:16 nM, NCI-H2170 HER2 YVMA cells:33 nM, BaF3 EGF dep cells:1540 nM, BaF3 HER2 WT cells:1 nM, A431 cells (EGFR wt amp):> 5000 nM
SynonymsBI 764532, BI 1810631
Chemical Properties
Molecular Weight535.6
FormulaC29H29N9O2
Cas No.2728667-27-2
SmilesN(C=1C2=C(C=NC(=N2)N3CCC(NC(C=C)=O)CC3)N=CN1)C4=CC(C)=C(OC=5C=C6C(=CC5)N(C)C=N6)C=C4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45.91 mg/mL (85.72 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.73 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8671 mL9.3353 mL18.6706 mL93.3532 mL
5 mM0.3734 mL1.8671 mL3.7341 mL18.6706 mL
10 mM0.1867 mL0.9335 mL1.8671 mL9.3353 mL
20 mM0.0934 mL0.4668 mL0.9335 mL4.6677 mL
50 mM0.0373 mL0.1867 mL0.3734 mL1.8671 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ZongertinibTyrosineKinasesTyrosine KinasesHER2BI-764532BI764532BI-1810631BI1810631
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