Ro15-4513

Name: Ro15-4513
Brand: TargetMol
SKU: T16775
Rating: 4.5 (1 reviews)

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Catalog No. T16775Cas No. 91917-65-6

Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.

Ro15-4513

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Catalog No. T16775Cas No. 91917-65-6

Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$143	5 days	5 days
25 mg	$882	6-8 weeks	6-8 weeks
50 mg	$1,170	6-8 weeks	6-8 weeks
100 mg	$1,770	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Ro15-4513 is imidazobenzodiazepinone derivative and is a partial inverse agonist of benzodiazepine receptors. Ro15-4513 is an effective ethanol antagonist.
In vitro	Ro15-4513 typically functions as a partial inverse agonist at GABAA receptors [3].
In vivo	Ro 15-4513 (i.p.; 3 mg/kg; 15 min before administration of 1.5 g/kg ethanol) reverses ethanol-induced sedation in GABAA receptor δ subunit-deficient mice. Ro 15-4513 (i.p.; 3 mg/kg; 10 min before being tested) fully inhibits the ethanol-induced (1.8 g/kg) reduction in total locomotor activity and partly the reduction in rearing [2].

Chemical Properties

Molecular Weight	326.31
Formula	C₁₅H₁₄N₆O₃
Cas No.	91917-65-6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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