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Anti-PDHA1 Antibody (9A259)

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Catalog No. TMAY-02750

Anti-PDHA1 Antibody (9A259) is a Rabbit antibody targeting PDHA1. Anti-PDHA1 Antibody (9A259) can be used in ICC/IF.

Anti-PDHA1 Antibody (9A259)

Anti-PDHA1 Antibody (9A259)

😃Good
Catalog No. TMAY-02750
Anti-PDHA1 Antibody (9A259) is a Rabbit antibody targeting PDHA1. Anti-PDHA1 Antibody (9A259) can be used in ICC/IF.
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100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-PDHA1 Antibody (9A259) is a Rabbit antibody targeting PDHA1. Anti-PDHA1 Antibody (9A259) can be used in ICC/IF.
Ig Type
Monoclonal Rabbit IgG
Clone
9A259
Reactivity
Human
Verified Activity
Immunofluorescence staining of PDHA1 in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human PDHA1 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm.
Application
ICC/IF
Recommended Dose
ICC-IF: 1:20-1:100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human PDHA1 (rh PDHA1; P08559-1Phe30-Ser390).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundPDHA1, also known as C54G1, is an alpha subunit of pyruvate dehydrogenase. Pyruvate dehydrogenase, together with dihydrolipoamide acetyltransferase and lipoamide dehydrogenase, composes the pyruvate dehydrogenase (PDH) complex. The PDH complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. PDHA1 plays a key role in the function of the PDH complex. Defects in PDHA1 can cause pyruvate dehydrogenase E1-alpha deficiency. Defects in PDHA1 also are the cause of X-linked Leigh syndrome (X-LS). X-LS is an early-onset progressive neurodegenerative disorder with a characteristic neuropathology consisting of focal, bilateral lesions in one or more areas of the central nervous system, including the brainstem, thalamus, basal ganglia, cerebellum, and spinal cord.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human PDHA1 Protein
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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