Activity has not been tested. It is theoretically active, but we cannot guarantee it.

CDKN2A/p16INK4a Protein, Human, Recombinant (GST) is expressed in E. coli. The accession number is P42771.

Human

E. coli

p16INK4A,p16-INK4,MTS-1,MTS1,Cyclin-dependent kinase inhibitor 2A,CDKN2A,CDKN2,CDK4I

Recombinant full length human p16INK4A was expressed in E. coli cells using a N-terminal GST tag.

>70% as determined by SDS-PAGE.

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

CDKN2A germline mutations increase the risk of melanoma development. CDKN2A/CDK4 were the first high-penetrance melanoma genes identified. CDKN2A suppresses the initiation of melanoma invasion through inhibition of BRN2. It's a potential prognostic role of CDKN2A/B deletions in early disease stratification in pediatric B-ALL. CDKN2A coding region germline variants are associated with pancreatic adenocarcinoma (PC) susceptibility.