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Anti-GRK2 Antibody (8P72) (Synonyms: Grk2, G-protein-coupled receptor kinase 2, Beta-ARK-1, Beta-adrenergic r...)

Catalog No. TMAC-01721 Copy Product Info
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Anti-GRK2 Antibody (8P72) is a Rabbit antibody targeting GRK2. Anti-GRK2 Antibody (8P72) can be used in IHC,WB.

Anti-GRK2 Antibody (8P72)

Copy Product Info
🥰Excellent
Catalog No. TMAC-01721
Synonyms Grk2, G-protein-coupled receptor kinase 2, Beta-ARK-1, Beta-adrenergic receptor kinase 1, Adrbk1

Anti-GRK2 Antibody (8P72) is a Rabbit antibody targeting GRK2. Anti-GRK2 Antibody (8P72) can be used in IHC,WB.

Anti-GRK2 Antibody
(8P72)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2977-10 days7-10 days
100 μL$4967-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-GRK2 Antibody (8P72) is a Rabbit antibody targeting GRK2. Anti-GRK2 Antibody (8P72) can be used in IHC,WB.
SynonymsGrk2, G-protein-coupled receptor kinase 2, Beta-ARK-1, Beta-adrenergic receptor kinase 1, Adrbk1
Ig Type
IgG
Clone
8P72
Reactivity
Human,Mouse,Rat
Verified Activity
1. Western blot analysis of GRK2 on Hela cell lysates using anti-GRK2 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-GRK2 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-GRK2 antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-GRK2 antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-GRK2 antibody. Counter stained with hematoxylin.
verifiedActivityverifiedActivityverifiedActivityverifiedActivityverifiedActivity
Application
Recommended Dose
WB: 1:1000-2000; IHC: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundHeterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of beta-adrenergic receptor kinase: GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 80 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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