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Anti-GRK2 Antibody (8P72)
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Catalog No. TMAC-01721
Alias Grk2, G-protein-coupled receptor kinase 2, Beta-ARK-1, Beta-adrenergic receptor kinase 1, Adrbk1
Anti-GRK2 Antibody (8P72) is a Rabbit antibody targeting GRK2. Anti-GRK2 Antibody (8P72) can be used in IHC,WB.
Anti-GRK2 Antibody (8P72)
Anti-GRK2 Antibody (8P72)
😃Good
Catalog No. TMAC-01721Alias Grk2, G-protein-coupled receptor kinase 2, Beta-ARK-1, Beta-adrenergic receptor kinase 1, Adrbk1
Anti-GRK2 Antibody (8P72) is a Rabbit antibody targeting GRK2. Anti-GRK2 Antibody (8P72) can be used in IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $297 | 7-10 days | 7-10 days | |
| 100 μL | $496 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-GRK2 Antibody (8P72) is a Rabbit antibody targeting GRK2. Anti-GRK2 Antibody (8P72) can be used in IHC,WB. |
| Synonyms | Grk2, G-protein-coupled receptor kinase 2, Beta-ARK-1, Beta-adrenergic receptor kinase 1, Adrbk1 |
| Ig Type | IgG |
| Clone | 8P72 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of GRK2 on Hela cell lysates using anti-GRK2 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-GRK2 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-GRK2 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-GRK2 antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-GRK2 antibody. Counter stained with hematoxylin.      |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of beta-adrenergic receptor kinase: GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 80 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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