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Anti-15-PGDH Antibody (8D922)
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Catalog No. TMAY-01748
Alias hydroxyprostaglandin dehydrogenase 15-(NAD), AV026552, 15-PGDH
Anti-15-PGDH Antibody (8D922) is a Mouse antibody targeting 15-PGDH. Anti-15-PGDH Antibody (8D922) can be used in WB,ELISA.
Anti-15-PGDH Antibody (8D922)
Anti-15-PGDH Antibody (8D922)
😃Good
Catalog No. TMAY-01748Alias hydroxyprostaglandin dehydrogenase 15-(NAD), AV026552, 15-PGDH
Anti-15-PGDH Antibody (8D922) is a Mouse antibody targeting 15-PGDH. Anti-15-PGDH Antibody (8D922) can be used in WB,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-15-PGDH Antibody (8D922) is a Mouse antibody targeting 15-PGDH. Anti-15-PGDH Antibody (8D922) can be used in WB,ELISA. |
| Alias | hydroxyprostaglandin dehydrogenase 15-(NAD), AV026552, 15-PGDH |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 8D922 |
| Reactivity | Human |
| Verified Activity | Anti-HPGD mouse monoclonal antibody at 1:500 dilution. -Lane A: LOVO Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:29 kDa |
| Application | WB,ELISA |
| Recommended Dose | WB: 1:500-1:1000; ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human HPGD / 15-PGDH (rh HPGD / 15-PGDH; TMPY-01264; NP_000851.2; Met 1-Gln 266). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human HPGD / 15-PGDH protein (TMPY-01264) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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