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Cobimetinib (R-enantiomer)

Name: Cobimetinib (R-enantiomer)
Brand: TargetMol
SKU: T10856
Rating: 4.5 (1 reviews)

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Catalog No. T10856Cas No. 934660-94-3

Alias XL-518 R-enantiomer, GDC-0973 R-enantiomer, Cobimetinib R-enantiomer

Cobimetinib R-enantiomer, the less active R-enantiomer of Cobimetinib, is a selective MEK inhibitor.

Cobimetinib (R-enantiomer)

😃Good

Catalog No. T10856Alias XL-518 R-enantiomer, GDC-0973 R-enantiomer, Cobimetinib R-enantiomerCas No. 934660-94-3

Cobimetinib R-enantiomer, the less active R-enantiomer of Cobimetinib, is a selective MEK inhibitor.

Pack Size	Price	Availability
25 mg	$3,030	3-6 months
50 mg	$3,910	3-6 months
100 mg	$4,830	3-6 months

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Product Introduction

Bioactivity

Description	Cobimetinib R-enantiomer, the less active R-enantiomer of Cobimetinib, is a selective MEK inhibitor.
Synonyms	XL-518 R-enantiomer, GDC-0973 R-enantiomer, Cobimetinib R-enantiomer

Chemical Properties

Molecular Weight	531.318
Formula	C₂₁H₂₁F₃IN₃O₂
Cas No.	934660-94-3
Relative Density.	1.706 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (188.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8821 mL	9.4106 mL	18.8211 mL	94.1056 mL
5 mM	0.3764 mL	1.8821 mL	3.7642 mL	18.8211 mL
10 mM	0.1882 mL	0.9411 mL	1.8821 mL	9.4106 mL
20 mM	0.0941 mL	0.4705 mL	0.9411 mL	4.7053 mL
50 mM	0.0376 mL	0.1882 mL	0.3764 mL	1.8821 mL
100 mM	0.0188 mL	0.0941 mL	0.1882 mL	0.9411 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc