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Anti-Phospho-EGFR (Tyr1092) Antibody (9I899)
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Catalog No. TMAH-00891
Alias PIG61, Phospho-EGFR (Y1092), p-EGFR (Y1092), p-EGFR (Tyr1092), NISBD2, mENA, LEGFR, HER1, ERBB1, ErbB, EGFR (p-Y1092), EGFR (p-Tyr1092), EGFR, EC 2.7.10.1, EC 2.7.10
Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) is an antibody targeting Phospho-EGFR (Tyr1092). Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) can be used in ELISA, WB.
Anti-Phospho-EGFR (Tyr1092) Antibody (9I899)
Anti-Phospho-EGFR (Tyr1092) Antibody (9I899)
😃Good
Catalog No. TMAH-00891Alias PIG61, Phospho-EGFR (Y1092), p-EGFR (Y1092), p-EGFR (Tyr1092), NISBD2, mENA, LEGFR, HER1, ERBB1, ErbB, EGFR (p-Y1092), EGFR (p-Tyr1092), EGFR, EC 2.7.10.1, EC 2.7.10
Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) is an antibody targeting Phospho-EGFR (Tyr1092). Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, WB Reactivity: Human |
| Alias | PIG61, Phospho-EGFR (Y1092), p-EGFR (Y1092), p-EGFR (Tyr1092), NISBD2, mENA, LEGFR, HER1, ERBB1, ErbB, EGFR (p-Y1092), EGFR (p-Tyr1092), EGFR, EC 2.7.10.1, EC 2.7.10 |
| Ig Type | Rabbit IgG |
| Clone | 9I899 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in A549 whole cell lysate,Hela whole cell lysate(treated with Pervanadate or EGF) -All lanes Phospho-EGFR antibody at 1.35μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 170 KDa -Observed band size: 170 KDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus.; [Isoform 2]: Secreted. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration. Plays a role in enhancing learning and memory performance. Isoform 2 may act as an antagonist of EGF action. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-EGFR (Y1092) |
| Antigen Species | Human |
| Gene ID | 1956 |
| Uniprot ID | |
| Biology Area | Signal Transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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