Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | Inquiry | $ 970.00 |
Description | Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA. |
Targets&IC50 | A/PR/8/34 (H1N1) with NA-H274Y:6.48 μM (IC50), Influenza A virus 690 (H3):7.13 μM (IC50), A/FM-1/1/47 (H1N1):3.58 μM (IC50), A/Aichi/2/68 (H3N2):5.26 μM (IC50), A/Puerto Rico/8/34 (H1N1):3.11 μM (IC50) |
In vitro | Treatment with Influenza A virus-IN-1 (compound 5-2; concentrations ranging from 5-40 μM; for 24 hours; in MDCK cells) notably diminishes the yield of influenza viral nucleoprotein (NP) and the expression level of NP protein in a dose-dependent manner. Additionally, this compound lowers influenza hemagglutinin (HA) mRNA expression at all assessed time points. It effectively hampers Influenza A virus (IAV) replication and curtails the production of NDAPH oxidase NOX1 in MDCK cells. Western Blot analysis conducted on IAV-infected MDCK cells treated with varying concentrations (5 μM, 10 μM, 20 μM, 40 μM) for 24 hours corroborates the significant reduction in influenza viral NP yields, evidencing a dose-responsive effect. |
Molecular Weight | 534.458 |
Formula | C27H20F6N2O3 |
CAS No. | 2250313-14-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Influenza A virus-IN-1 2250313-14-3 Influenza A virus IN 1 Influenza A virusIN1 inhibitor inhibit