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Influenza A virus-IN-1
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Catalog No. T39778Cas No. 2250313-14-3
Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.
Influenza A virus-IN-1
😃Good
Catalog No. T39778Cas No. 2250313-14-3
Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $970 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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| Description | Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA. |
| Targets&IC50 | A/FM-1/1/47 (H1N1):3.58 μM (IC50), Influenza A virus 690 (H3):7.13 μM (IC50), A/PR/8/34 (H1N1) with NA-H274Y:6.48 μM (IC50), A/Aichi/2/68 (H3N2):5.26 μM (IC50), A/Puerto Rico/8/34 (H1N1):3.11 μM (IC50) |
| In vitro | Treatment with Influenza A virus-IN-1 (compound 5-2; concentrations ranging from 5-40 μM; for 24 hours; in MDCK cells) notably diminishes the yield of influenza viral nucleoprotein (NP) and the expression level of NP protein in a dose-dependent manner. Additionally, this compound lowers influenza hemagglutinin (HA) mRNA expression at all assessed time points. It effectively hampers Influenza A virus (IAV) replication and curtails the production of NDAPH oxidase NOX1 in MDCK cells. Western Blot analysis conducted on IAV-infected MDCK cells treated with varying concentrations (5 μM, 10 μM, 20 μM, 40 μM) for 24 hours corroborates the significant reduction in influenza viral NP yields, evidencing a dose-responsive effect. |
| Molecular Weight | 534.458 |
| Formula | C27H20F6N2O3 |
| Cas No. | 2250313-14-3 |
| Smiles | CCOC(=O)C1=C(Nc2ccc(cc2)C(F)(F)F)C(=O)N(C1c1ccccc1)c1ccc(cc1)C(F)(F)F |c:5| |
| Relative Density. | 1.406 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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