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YM-1

Name: YM-1
Brand: TargetMol
SKU: T73579
Rating: 4.5 (1 reviews)

Catalog No. T73579 Copy Product Info

Purity: 99.58%

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YM-1 is an HSP70 modulator and an allosteric inhibitor. It promotes the degradation of client proteins (e.g., Akt, Raf-1), used for cancer and antiviral research.

YM-1

Copy Product Info

🥰Excellent

Catalog No. T73579

YM-1 is an HSP70 modulator and an allosteric inhibitor. It promotes the degradation of client proteins (e.g., Akt, Raf-1), used for cancer and antiviral research.

Cas No. 409086-68-6

Pack Size	Price	USA Stock	Global Stock
25 mg	Inquiry	-	In Stock
50 mg	Inquiry	-	In Stock
100 mg	Inquiry	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.58%

Appearance:Solid

Color:Red

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Product Introduction

Bioactivity

Description	YM-1 is an HSP70 modulator and an allosteric inhibitor. It promotes the degradation of client proteins (e.g., Akt, Raf-1), used for cancer and antiviral research.
Targets&IC50	Hsp70:8.2 μM
In vitro	YM-1 (IC50 = 8.2 μM) is an Hsp70 activator that induces growth arrest in HeLa cells by modulating p53, p21, and FoxM1 [1].
In vivo	YM-1 (1 mM, 7 days) activates the Hsp70 pathway to rescue eye degeneration in Drosophila polyQ models [1].

Chemical Properties

Molecular Weight	417.98
Formula	C₂₀H₂₀ClN₃OS₂
Cas No.	409086-68-6
Smiles	[Cl-].O=C1C(SC(=CC=2C=CC=C[N+]2C)N1CC)=C3SC=4C=CC=CC4N3C

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (95.7 mM), Sonication is recommmended.

DMSO: 24 mg/mL (57.42 mM), Sonication is recommmended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3925 mL	11.9623 mL	23.9246 mL	119.6229 mL
5 mM	0.4785 mL	2.3925 mL	4.7849 mL	23.9246 mL
10 mM	0.2392 mL	1.1962 mL	2.3925 mL	11.9623 mL
20 mM	0.1196 mL	0.5981 mL	1.1962 mL	5.9811 mL
50 mM	0.0478 mL	0.2392 mL	0.4785 mL	2.3925 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

YM-1

YM-1

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In Vivo Formulation Calculator (Clear solution)

Dose Conversion

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