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2-Chloronaphthoquinone

Name: 2-Chloronaphthoquinone
Brand: TargetMol
SKU: T7075
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7075Cas No. 1010-60-2

Alias 2-Chloro-1,4-naphthoquinone

2-Chloronaphthoquinone (2-Chloro-1,4-naphthoquinone) is a substituted naphthoquinone which is used as an insecticide and acaricide.

2-Chloronaphthoquinone

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Purity: 99.98%

Catalog No. T7075Alias 2-Chloro-1,4-naphthoquinoneCas No. 1010-60-2

2-Chloronaphthoquinone (2-Chloro-1,4-naphthoquinone) is a substituted naphthoquinone which is used as an insecticide and acaricide.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	In Stock	In Stock
1 g	$56	In Stock	In Stock
5 g	$113	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

2-Chloronaphthoquinone AI Summary

2-Chloronaphthoquinone is characterized by moderate lipophilicity, as indicated by partition coefficient values (LogP) ranging from 2.15 to 2.29. It shows a moderate to high capacity for distribution in chromatographic systems, suggesting potential in drug permeability or affinity processes. The compound exhibits notable biological activities, including trypanocidal activity against the bloodstream form of Trypanosoma cruzi Y, with an IC50 of 12300.0 nM. It also shows cytotoxicity against mouse embryo cells (HMC), with an LC50 of 41300.0 nM, yielding a selectivity index of 3.6. In human cells, 2-Chloronaphthoquinone displays cytotoxicity against THLE cells with varying EC50 values (21100.0 nM at 4 hrs, 13800.0 nM at 24 hrs, and 37400.0 nM at 72 hrs) and induces ROS generation with an EC50 of 2500.0 nM. Cytotoxic activity is also observed against WI38 and HL60 cells, with IC50 values of 21580.0 nM for WI38 cells, and 6320.0 nM and 11480.0 nM for HL60 cells at 48 and 24 hours, respectively, showing a selectivity index of 3.32 favoring HL60 cells. Additionally, 2-Chloronaphthoquinone inhibits Schistosoma mansoni DHODH enzyme activity by 46.0% at a concentration of 250 uM using a DCIP reduction-based assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2-Chloronaphthoquinone (2-Chloro-1,4-naphthoquinone) is a substituted naphthoquinone which is used as an insecticide and acaricide.
Synonyms	2-Chloro-1,4-naphthoquinone

Chemical Properties

Molecular Weight	192.6
Formula	C₁₀H₅ClO₂
Cas No.	1010-60-2
Smiles	ClC1=CC(=O)C2=C(C=CC=C2)C1=O
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (311.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1921 mL	25.9605 mL	51.9211 mL	259.6054 mL
5 mM	1.0384 mL	5.1921 mL	10.3842 mL	51.9211 mL
10 mM	0.5192 mL	2.5961 mL	5.1921 mL	25.9605 mL
20 mM	0.2596 mL	1.2980 mL	2.5961 mL	12.9803 mL
50 mM	0.1038 mL	0.5192 mL	1.0384 mL	5.1921 mL
100 mM	0.0519 mL	0.2596 mL	0.5192 mL	2.5961 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc