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NOTA-IMB-RGD
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Catalog No. T212400
NOTA-IMB-RGD is a dual-molecule probe that targets integrin αvβ3 (integrinαvβ3) and programmed death-ligand 1 (PD-L1). It can block the PD-1/PD-L1 signaling pathway and the tumor vasculature with overexpressed integrin αvβ3. This compound holds potential for research in solid tumors co-expressing PD-L1 and αvβ3, such as gliomas and breast cancer.
NOTA-IMB-RGD
NOTA-IMB-RGD
😃Good
Catalog No. T212400
NOTA-IMB-RGD is a dual-molecule probe that targets integrin αvβ3 (integrinαvβ3) and programmed death-ligand 1 (PD-L1). It can block the PD-1/PD-L1 signaling pathway and the tumor vasculature with overexpressed integrin αvβ3. This compound holds potential for research in solid tumors co-expressing PD-L1 and αvβ3, such as gliomas and breast cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | NOTA-IMB-RGD is a dual-molecule probe that targets integrin αvβ3 (integrinαvβ3) and programmed death-ligand 1 (PD-L1). It can block the PD-1/PD-L1 signaling pathway and the tumor vasculature with overexpressed integrin αvβ3. This compound holds potential for research in solid tumors co-expressing PD-L1 and αvβ3, such as gliomas and breast cancer. |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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