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LY 345899

Name: LY 345899
Brand: TargetMol
SKU: T15827
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15827Cas No. 10538-99-5

LY 345899 is a folate analog that inhibits methylenetetrahydrofolate dehydrogenase and MTHFD2, with IC50 values of 96 nM and 663 nM, respectively, and a Ki of 18 nM for MTHFD1.

LY 345899

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Purity: 99.7%

Catalog No. T15827Cas No. 10538-99-5

LY 345899 is a folate analog that inhibits methylenetetrahydrofolate dehydrogenase and MTHFD2, with IC50 values of 96 nM and 663 nM, respectively, and a Ki of 18 nM for MTHFD1.

Pack Size	Price	Availability
1 mg	$40	In Stock
5 mg	$163	In Stock
10 mg	$248	In Stock
25 mg	$433	In Stock
50 mg	$595	In Stock
100 mg	$852	In Stock
200 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$168	In Stock

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Batch Information

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Purity:99.7%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	LY 345899 is a folate analog that inhibits methylenetetrahydrofolate dehydrogenase and MTHFD2, with IC50 values of 96 nM and 663 nM, respectively, and a Ki of 18 nM for MTHFD1.
Targets&IC50	MTHFD1:18 nM (Ki), MTHFD1:IC50 : 96 nM, MTHFD2:663 nM (Ki)

Chemical Properties

Molecular Weight	471.42
Formula	C₂₀H₂₁N₇O₇
Cas No.	10538-99-5
Smiles	Nc1nc2NCC3CN(C(=O)N3c2c(=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Relative Density.	1.82 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (127.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1213 mL	10.6063 mL	21.2125 mL	106.0625 mL
5 mM	0.4243 mL	2.1213 mL	4.2425 mL	21.2125 mL
10 mM	0.2121 mL	1.0606 mL	2.1213 mL	10.6063 mL
20 mM	0.1061 mL	0.5303 mL	1.0606 mL	5.3031 mL
50 mM	0.0424 mL	0.2121 mL	0.4243 mL	2.1213 mL
100 mM	0.0212 mL	0.1061 mL	0.2121 mL	1.0606 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc