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KU 59403

Name: KU 59403
Brand: TargetMol
SKU: T15673
Rating: 4.5 (1 reviews)

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Catalog No. T15673Cas No. 845932-30-1

Alias KU-59403, KU59403

KU 59403 is a selective and potent ATM inhibitor with antitumor and anticancer activity, inhibits ATM, DNA-PK and PI3K, and is often used in combination therapy with PARP or ATR inhibitors to slow the progression of cancer.

KU 59403

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Purity: 99.10%

Catalog No. T15673Alias KU-59403, KU59403Cas No. 845932-30-1

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$882	10-14 weeks	10-14 weeks
50 mg	$1,170	10-14 weeks	10-14 weeks
100 mg	$1,770	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.10%

Appearance:Solid

Color:Yellow

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COA LCMS

Product Introduction

Bioactivity

Description	KU 59403 is a selective and potent ATM inhibitor with antitumor and anticancer activity, inhibits ATM, DNA-PK and PI3K, and is often used in combination therapy with PARP or ATR inhibitors to slow the progression of cancer.
Targets&IC50	ATM:3 nM
In vitro	In LoVo, HCT116, and SW620, U2OS, and MDA-MB-231 cells, KU 59403 (1 μM; 16 hours) exhibited at least 1000-fold specificity for ATM over other tested members of the PI3K family[1].
In vivo	KU59403 at a daily dose of 12.5 mg/kg induces sensitization, while increasing the dose to 25 mg/kg twice daily results in the greatest chemo-sensitisation. Without significantly increased toxicity, it exhibits a 3-fold increase in BMY-40481-induced tumor growth delay in SW620 and HCT116-N7 xenografts [1].
Synonyms	KU-59403, KU59403

Chemical Properties

Molecular Weight	564.72
Formula	C₂₉H₃₂N₄O₄S₂
Cas No.	845932-30-1
Smiles	CN1CCN(CCC(=O)Nc2ccc3Sc4c(Sc3c2)cccc4-c2cc(=O)cc(o2)N2CCOCC2)CC1
Relative Density.	1.368 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (8.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7708 mL	8.8539 mL	17.7079 mL	88.5395 mL
5 mM	0.3542 mL	1.7708 mL	3.5416 mL	17.7079 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc