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NaV1.7 inhibitor-1

🥰Excellent
Catalog No. T12181Cas No. 1494585-79-3

NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).

NaV1.7 inhibitor-1

NaV1.7 inhibitor-1

🥰Excellent
Purity: 99.89%
Catalog No. T12181Cas No. 1494585-79-3
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$106In StockIn Stock
5 mg$268In StockIn Stock
10 mg$428In StockIn Stock
25 mg$737In StockIn Stock
50 mg$987In StockIn Stock
100 mg$1,450In StockIn Stock
1 mL x 10 mM (in DMSO)$295In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).
Targets&IC50
Nav1.7 (human):0.6 nM
Chemical Properties
Molecular Weight435.55
FormulaC23H30FNO4S
Cas No.1494585-79-3
SmilesCC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC2(CC2)CC1
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (206.64 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2959 mL11.4797 mL22.9595 mL114.7974 mL
5 mM0.4592 mL2.2959 mL4.5919 mL22.9595 mL
10 mM0.2296 mL1.1480 mL2.2959 mL11.4797 mL
20 mM0.1148 mL0.5740 mL1.1480 mL5.7399 mL
50 mM0.0459 mL0.2296 mL0.4592 mL2.2959 mL
100 mM0.0230 mL0.1148 mL0.2296 mL1.1480 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SodiumChannelSodium ChannelNaV1.7 inhibitor-1NaV-1.7 inhibitor-1NaV1.7 inhibitor1NaV1.7 inhibitor 1Nav1.7 channelNa+ channelsNa channelsInhibitorinhibit
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