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GLPG2451

Name: GLPG2451
Brand: TargetMol
SKU: T13705
Rating: 4.5 (1 reviews)

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Catalog No. T13705Cas No. 2055015-61-5

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that effectively enhances the function of low-temperature-rescued F508del CFTR with an EC50 of 11.1 nM.

GLPG2451

😃Good

Catalog No. T13705Cas No. 2055015-61-5

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that effectively enhances the function of low-temperature-rescued F508del CFTR with an EC50 of 11.1 nM.

Pack Size	Price	Availability
5 mg	$297	6-8 weeks
25 mg	$987	6-8 weeks
50 mg	$1,360	6-8 weeks
100 mg	$1,860	6-8 weeks
1 mL x 10 mM (in DMSO)	$365	6-8 weeks

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Product Introduction

Bioactivity

Description

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that effectively enhances the function of low-temperature-rescued F508del CFTR with an EC50 of 11.1 nM.

Chemical Properties

Molecular Weight	419.38
Formula	C₁₆H₁₆F₃N₃O₅S
Cas No.	2055015-61-5
Relative Density.	1.471 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 270 mg/mL (643.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3845 mL	11.9224 mL	23.8447 mL	119.2236 mL
5 mM	0.4769 mL	2.3845 mL	4.7689 mL	23.8447 mL
10 mM	0.2384 mL	1.1922 mL	2.3845 mL	11.9224 mL
20 mM	0.1192 mL	0.5961 mL	1.1922 mL	5.9612 mL
50 mM	0.0477 mL	0.2384 mL	0.4769 mL	2.3845 mL
100 mM	0.0238 mL	0.1192 mL	0.2384 mL	1.1922 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc