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Deferasirox (Fe3+ chelate)

Name: Deferasirox (Fe3+ chelate)
Brand: TargetMol
SKU: T13639
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13639Cas No. 554435-83-5

Deferasirox (Fe3+ chelate) is an orally available iron chelator with potential anticancer activity, inhibits the anti-apoptotic activity of MCL-1, and can be used to study iron overload.

Deferasirox (Fe3+ chelate)

🥰Excellent

Catalog No. T13639Cas No. 554435-83-5

Deferasirox (Fe3+ chelate) is an orally available iron chelator with potential anticancer activity, inhibits the anti-apoptotic activity of MCL-1, and can be used to study iron overload.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$98	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:≥98.0%

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Product Introduction

Bioactivity

Description	Deferasirox (Fe3+ chelate) is an orally available iron chelator with potential anticancer activity, inhibits the anti-apoptotic activity of MCL-1, and can be used to study iron overload.
In vitro	Deferasirox (Fe3+ chelate) promotes cell cycle arrest in cervical cancer cell lines by regulating the expression of cell cycle regulatory factors cyclin D1, cyclin E, and proliferating cell nuclear antigen (PCNA)[1].

Chemical Properties

Molecular Weight	426.18
Formula	C₂₁H₁₂FeN₃O₄
Cas No.	554435-83-5
Smiles	O=C([O-])C1=CC=C(C=C1)N2N=C3C=4C=CC=CC4[O-][Fe+3]5[O-]C=6C=CC=CC6C2=[N]35
Relative Density.	no data available
Color	Black
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (70.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3464 mL	11.7321 mL	23.4643 mL	117.3213 mL
5 mM	0.4693 mL	2.3464 mL	4.6929 mL	23.4643 mL
10 mM	0.2346 mL	1.1732 mL	2.3464 mL	11.7321 mL
20 mM	0.1173 mL	0.5866 mL	1.1732 mL	5.8661 mL
50 mM	0.0469 mL	0.2346 mL	0.4693 mL	2.3464 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc