Shopping Cart

Your shopping cart is currently empty

Malic acid

Name: Malic acid
Brand: TargetMol
SKU: T2S0850
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T2S0850Cas No. 6915-15-7

Alias Pomalus acid, Hydroxybutanedioic acid, FDA 2018, E 296, Deoxytetraric acid, 2-Hydroxysuccinic acid

1. Malic acid (Pomalus acid) did reduce populations of L. monocytogenes on poultry. 2. Malic acid supplementation may be useful for conservative treatment of calcium renal stone disease by virtue of its capacity to induce these effects.

Malic acid

Copy Product Info

😃Good

Purity: 99.86%

Catalog No. T2S0850Alias Pomalus acid, Hydroxybutanedioic acid, FDA 2018, E 296, Deoxytetraric acid, 2-Hydroxysuccinic acidCas No. 6915-15-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$31	-	In Stock
10 g	$40	-	In Stock
25 g	$52	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Malic acid AI Summary

Malic acid demonstrates a range of bioactivities across various biological targets. It exhibits potent inhibitory activity against AmpC Beta-Lactamase (79,432.8 nM), JMJD2A-Tudor Domain (89,125.1 nM), Histone Lysine Methyltransferase G9a (39,810.7 nM), BAZ2B (89,125.1 nM), and has strong inhibition against malarial parasite plastid (11,689.1 nM) and PTHR (39,810.7 nM). Additionally, it inhibits Human Apurinic/apyrimidinic Endonuclease 1 (APE1) with a potency of 158,489.3 nM. The compound also exhibits nematotoxic activity against Meloidogyne incognita J2 with an EC50 value greater than 1000.0 µg/mL. Despite showing weak inhibitory activity against human hexahistidine-tagged full-length FTO with an IC50 value of >1,000,000.0 nM, it has notable antioxidant activity, inhibiting lipid peroxidation with an IC50 of 97,700.0 nM. In the context of antiviral properties, Malic acid inhibits SARS-CoV-2 induced cytotoxicity in Caco-2, HRCE, and VERO-6 cells, although with relatively moderate efficacy. It shows varying inhibition of SARS-CoV-2 3CL-Pro protease and also exhibits minor inhibitory activity in HDAC6 enzymatic assays. Overall, Malic acid appears to be a versatile compound with bioactivities in enzyme inhibition, antimicrobial, nematotoxic, antioxidant, and antiviral areas, albeit with varying degrees of potency that suggests potential for further development and optimization..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Malic acid (Pomalus acid) did reduce populations of L. monocytogenes on poultry. 2. Malic acid supplementation may be useful for conservative treatment of calcium renal stone disease by virtue of its capacity to induce these effects.
Synonyms	Pomalus acid, Hydroxybutanedioic acid, FDA 2018, E 296, Deoxytetraric acid, 2-Hydroxysuccinic acid

Chemical Properties

Molecular Weight	134.09
Formula	C₄H₆O₅
Cas No.	6915-15-7
Smiles	OC(CC(O)=O)C(O)=O
Relative Density.	1.609 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242 mg/mL (1804.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (37.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.4577 mL	37.2884 mL	74.5768 mL	372.8839 mL
5 mM	1.4915 mL	7.4577 mL	14.9154 mL	74.5768 mL
10 mM	0.7458 mL	3.7288 mL	7.4577 mL	37.2884 mL
20 mM	0.3729 mL	1.8644 mL	3.7288 mL	18.6442 mL
50 mM	0.1492 mL	0.7458 mL	1.4915 mL	7.4577 mL
100 mM	0.0746 mL	0.3729 mL	0.7458 mL	3.7288 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc