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BAY-069

Catalog No. T67927 CAS 2639638-66-5

BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM. BAY-069 is a novel (trifluoromethyl) pyrimidine dione chemical probe, which can be used for anticancer research.

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BAY-069, CAS 2639638-66-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 152.00
5 mg	In stock	$ 378.00
10 mg	In stock	$ 563.00
25 mg	In stock	$ 890.00
50 mg	In stock	$ 1,230.00
100 mg	In stock	$ 1,670.00
500 mg	In stock	$ 3,350.00
1 mL * 10 mM (in DMSO)	In stock	$ 429.00

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Purity: 98.83%

Biological Description

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Description	BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM. BAY-069 is a novel (trifluoromethyl) pyrimidine dione chemical probe, which can be used for anticancer research.
Targets&IC50	BCAT2:153 nM, BCAT1:31 nM
In vitro	BAY-069, inhibits the proliferation of U-87 and MDA-MB-231 cells. The compound is tested at concentrations ranging from 70 nM to 50 μM, with a duration of 72 hours. In U-87 cells, the IC50 is determined to be 358 nM, while in MDA-MB-231 cells, the IC50 is 874 nM [1].
In vivo	BAY-069 demonstrates high metabolic stability when incubated with human liver microsomes, with a blood clearance of 0.11 L/h/kg. It also shows moderate metabolic stability when incubated with rat hepatocytes, with a blood clearance of 1.8 L/h/kg. BAY-069 exhibits high permeability through Caco-2 cell monolayers without any signs of efflux [1].

Molecular Weight	446.81
Formula	C22H14ClF3N2O3
CAS No.	2639638-66-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (61.55 mM)

References and Literature

1. Günther J, et al. BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J Med Chem. 2022;65(21):14366-14390.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max NF-κB Signaling Compound Library Mitochondria-Targeted Compound Library Anti-Cancer Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BAY-069 2639638-66-5 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species BAY 069 BAY069 inhibitor inhibit

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