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Anti-PKN1 Monoclonal Antibody (7Z575)
(Synonyms: PRKCL1, PRK1, PKN-ALPHA, PKN, PAK-1, PAK1, DBK) Copy Product Info
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Synonyms: PRKCL1, PRK1, PKN-ALPHA, PKN, PAK-1, PAK1, DBK
Catalog No. TMAC-03354 Copy Product Info
🥰Excellent
Anti-PKN1 Monoclonal Antibody (7Z575) is a Mouse antibody targeting PKN1. Anti-PKN1 Monoclonal Antibody (7Z575) can be used in IHC,IF,FCM.
Anti-PKN1 Monoclonal Antibody
(7Z575)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $298 | 7-10 days | 7-10 days | |
| 100 µL | $427 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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| Description | Anti-PKN1 Monoclonal Antibody (7Z575) is a Mouse antibody targeting PKN1. Anti-PKN1 Monoclonal Antibody (7Z575) can be used in IHC,IF,FCM. |
| Synonyms | PRKCL1, PRK1, PKN-ALPHA, PKN, PAK-1, PAK1, DBK |
| Ig Type | IgG2b |
| Clone | 7Z575 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of PKN1 on human PKN1 recombinant protein using anti-PKN1 antibody at 1/1,000 dilution. 2. Western blot analysis of PKN1 on HEK293 (1) and PKN1-hIgGFc transfected HEK293 (2) cell lysate using anti-PKN1 antibody at 1/1,000 dilution. 3. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-PKN1 antibody. Counter stained with hematoxylin. 4. ICC staining PKN1 (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. Flow cytometric analysis of Hela cells with PKN1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).  , , , , |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human PKN1 (AA: 442-620) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | PKN1 |
| Gene ID | |
| Protein Name | Serine/threonine-protein kinase N1 |
| Uniprot ID |
| Molecular Weight | Theoretical: 104 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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