Anti-inflammatory agent 107

Name: Anti-inflammatory agent 107
Brand: TargetMol
SKU: T214434
Rating: 4.5 (1 reviews)

Catalog No. T214434 Copy Product Info

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Anti-inflammatory agent 107 is an orally effective compound that serves as a potent anti-inflammatory agent. It inhibits NF-κB with a strong binding affinity of -9.4578 kcal/mol. The agent reduces levels of inflammatory markers such as TNF-α, IL-6, INF-γ, NF-κβ, CRP (C-reactive protein), and ESR (Erythrocyte Sedimentation Rate). Additionally, it enhances the activity of endogenous antioxidant systems by increasing SOD (superoxide dismutase), CAT (catalase), and GSH (glutathione). Notably, Anti-inflammatory agent 107 exhibits no hepatic or renal toxicity and provides significant protective effects for the liver and kidneys. It also improves leukocyte infiltration and tissue edema in a dose-dependent manner, making it valuable for anti-inflammatory research.

Anti-inflammatory agent 107

Copy Product Info

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Catalog No. T214434

Anti-inflammatory agent 107

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Bioactivity

Description	Anti-inflammatory agent 107 is an orally effective compound that serves as a potent anti-inflammatory agent. It inhibits NF-κB with a strong binding affinity of -9.4578 kcal/mol. The agent reduces levels of inflammatory markers such as TNF-α, IL-6, INF-γ, NF-κβ, CRP (C-reactive protein), and ESR (Erythrocyte Sedimentation Rate). Additionally, it enhances the activity of endogenous antioxidant systems by increasing SOD (superoxide dismutase), CAT (catalase), and GSH (glutathione). Notably, Anti-inflammatory agent 107 exhibits no hepatic or renal toxicity and provides significant protective effects for the liver and kidneys. It also improves leukocyte infiltration and tissue edema in a dose-dependent manner, making it valuable for anti-inflammatory research.
In vitro	Anti-inflammatory agent 107 (compound 4D) demonstrates potent anti-inflammatory effects by inhibiting the NF-κB signaling pathway, with a docking score of -9.4578 kcal/mol. In experiments on human red blood cell membrane stabilization (antihemolytic) and protein denaturation inhibition, its concentration (50 μg/mL in 2 mL system, 50 μg/mL in 0.02 mL system) also showed strong anti-inflammatory activity.
In vivo	Compound 4D, known as Anti-inflammatory agent 107, administered orally at a dose of 20-50 μg/kg once daily for one week, has been shown to decrease levels of inflammatory biomarkers, enhance and restore the antioxidant defense system (GSH, CAT, SOD), alleviate nephrotoxicity, and reduce leukocyte infiltration in a rat model of κ-Carrageenan-induced paw edema.

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc