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BMS-986449
🥰Excellent
Catalog No. T204091
BMS-986449 is a CELMoD-type molecular glue that can promote the degradation of IKZF2 (Helios) and IKZF4 (Eos). It targets Helios and Eos for degradation by guiding the E3 ubiquitin ligase Cereblon, thereby reshaping the function of regulatory T cells (Tregs) and enhancing their anti-tumor immune response. BMS-986449 has potential application prospects in the study of advanced solid tumors.
BMS-986449
BMS-986449
🥰Excellent
Catalog No. T204091
BMS-986449 is a CELMoD-type molecular glue that can promote the degradation of IKZF2 (Helios) and IKZF4 (Eos). It targets Helios and Eos for degradation by guiding the E3 ubiquitin ligase Cereblon, thereby reshaping the function of regulatory T cells (Tregs) and enhancing their anti-tumor immune response. BMS-986449 has potential application prospects in the study of advanced solid tumors.
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Product Introduction
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Chemical Properties
| Description | BMS-986449 is a CELMoD-type molecular glue that can promote the degradation of IKZF2 (Helios) and IKZF4 (Eos). It targets Helios and Eos for degradation by guiding the E3 ubiquitin ligase Cereblon, thereby reshaping the function of regulatory T cells (Tregs) and enhancing their anti-tumor immune response. BMS-986449 has potential application prospects in the study of advanced solid tumors. |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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