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Boc-gly-PEG3-endo-BCN

Boc-gly-PEG3-endo-BCN
Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker and a cleavable 2-unit PEG ADC linker, used in the synthesis of PROTACs [1] and antibody-drug conjugates (ADCs) [2], respectively.
Catalog No. T14726Cas No. 2110444-63-6

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Boc-gly-PEG3-endo-BCN

Catalog No. T14726Cas No. 2110444-63-6

Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker and a cleavable 2-unit PEG ADC linker, used in the synthesis of PROTACs [1] and antibody-drug conjugates (ADCs) [2], respectively.
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Product Introduction

Bioactivity
Description
Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker and a cleavable 2-unit PEG ADC linker, used in the synthesis of PROTACs [1] and antibody-drug conjugates (ADCs) [2], respectively.
In vitro
PROTACs consist of two ligands linked by a connector: one targets an E3 ubiquitin ligase, and the other targets a specific protein, utilizing the intracellular ubiquitin-proteasome system for selective degradation of target proteins[1]. ADCs are composed of an antibody conjugated to an ADC cytotoxin via an ADC linker[2].
Chemical Properties
Molecular Weight553.69
FormulaC28H47N3O8
Cas No.2110444-63-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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