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Anti-EIF2AK2 Antibody (3D60)
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Catalog No. TMAC-03357
Alias eIF2A protein kinase2
Anti-EIF2AK2 Antibody (3D60) is a Rabbit antibody targeting EIF2AK2. Anti-EIF2AK2 Antibody (3D60) can be used in WB,ICC/IF,IHC,IP.
Anti-EIF2AK2 Antibody (3D60)
Anti-EIF2AK2 Antibody (3D60)
😃Good
Catalog No. TMAC-03357Alias eIF2A protein kinase2
Anti-EIF2AK2 Antibody (3D60) is a Rabbit antibody targeting EIF2AK2. Anti-EIF2AK2 Antibody (3D60) can be used in WB,ICC/IF,IHC,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-EIF2AK2 Antibody (3D60) is a Rabbit antibody targeting EIF2AK2. Anti-EIF2AK2 Antibody (3D60) can be used in WB,ICC/IF,IHC,IP. |
| Synonyms | eIF2A protein kinase2 |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of PKR on different lysates using anti-PKR antibody at 1/1,000 dilution. Positive control: Lane 1: MCF-7, Lane 2: Hela. 2. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PKR antibody. Counter stained with hematoxylin. 3. ICC staining PKR in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| Application | |
| Recommended Dose | WB: 1:1000-5000; IHC: 1:50-100; ICC/IF: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | An interferon-inducible, RNA-dependent protein serine/threonine kinase (PKR) has been described. PKR in earlier literature is variously known as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the a subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2a on serine-51 results in inhibition of translation. Molecular cDNA clones have been isolated from both human and mouse cells. The serine/threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. Three kinds of regulation of PKR enzymatic activity have been described. These include transcriptional regulation in response to interferon, an autoregulatory mechanism controlling PKR expression at the level of translation and post-translational regulation by RNA mediated autophosphorylation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 68 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Tyrosine-protein kinase EIF2AK2Protein kinase RNA-activated (PKRProtein kinase R)PRKRPKRp68 kinaseP1/eIF-2A protein kinaseInterferon-inducible RNA-dependent protein kinaseInterferon-induced, double-stranded RNA-activated protein kinaseEukaryotic translation initiation factor 2-α kinase 2 (eIF-2A protein kinase 2)Eukaryotic translation initiation factor 2-alpha kinase 2 (eIF-2A protein kinase 2)Eukaryotic translation initiation factor 2-a kinase 2 (eIF-2A protein kinase 2)EIF2AK2EIF2AK 2eIF-2A protein kinase 2double-stranded RNA-activated protein kinase
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