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Anti-GRP78/Bip Antibody (4S162)

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Catalog No. TMAB-06799

Anti-GRP78/Bip Antibody (4S162) is a Mouse antibody targeting GRP78/Bip. Anti-GRP78/Bip Antibody (4S162) can be used in WB,ICC/IF.

Anti-GRP78/Bip Antibody (4S162)

Anti-GRP78/Bip Antibody (4S162)

😃Good
Catalog No. TMAB-06799
Anti-GRP78/Bip Antibody (4S162) is a Mouse antibody targeting GRP78/Bip. Anti-GRP78/Bip Antibody (4S162) can be used in WB,ICC/IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 μg$1,0607-10 days7-10 days
50 μL$2207-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-GRP78/Bip Antibody (4S162) is a Mouse antibody targeting GRP78/Bip. Anti-GRP78/Bip Antibody (4S162) can be used in WB,ICC/IF.
Ig Type
IgG
Clone
4S162
Reactivity
Human (predicted:Rat)
Application
WB
ICC/IF
Recommended Dose
WB: 1:500-1000; ICC/IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationEndoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human GRP78/Bip
Antigen Species
Human
Gene Name
HSPA5
Gene ID
3309
Protein Name
Endoplasmic reticulum chaperone BiP
Uniprot ID
P11021
Function
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
Chemical Properties
Molecular WeightTheoretical: 78 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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