Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His)

Name: Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His)
Brand: TargetMol
SKU: TMPH-01931
Rating: 4.5 (1 reviews)

(Synonyms: Protein cereblon, CRBN) Copy Product Info

Synonyms: Protein cereblon, CRBN

Catalog No. TMPH-01931 Copy Product Info

Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His) is expressed in in vitro E. coli expression system.

Pack Size	Price	USA Stock	Global Stock
5 µg	$276	20 days	20 days
10 µg	$463	20 days	20 days
20 µg	$780	20 days	20 days
50 µg	$987	20 days	20 days
100 µg	$1,260	20 days	20 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:87%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His) is expressed in in vitro E. coli expression system.
Species	Human
Expression System	E. coli
Tag	C-6xHis
Accession Number	Q96SW2
Amino Acid	MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
Construction	1-442 aa
Protein Purity	> 90% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	Protein cereblon, CRBN
Research Background	Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.

Chemical Properties

Molecular Weight

51.2 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Dose Conversion

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Tech Support

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Related Tags: Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His) chemical structure | Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His) molecular weight