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HDAC6-IN-44
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Catalog No. T210360
HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC50 value of 8.97 nM. It can suppress idiopathic pulmonary fibrosis phenotypes and exhibits anti-fibrotic activity in the lungs. Additionally, HDAC6-IN-44 has been shown to inhibit fibrosis progression in a bleomycin-induced mouse model and demonstrates good metabolic stability, making it a promising candidate for idiopathic pulmonary fibrosis research.
HDAC6-IN-44
HDAC6-IN-44
Copy Product Info😃Good
Catalog No. T210360
HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC50 value of 8.97 nM. It can suppress idiopathic pulmonary fibrosis phenotypes and exhibits anti-fibrotic activity in the lungs. Additionally, HDAC6-IN-44 has been shown to inhibit fibrosis progression in a bleomycin-induced mouse model and demonstrates good metabolic stability, making it a promising candidate for idiopathic pulmonary fibrosis research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC50 value of 8.97 nM. It can suppress idiopathic pulmonary fibrosis phenotypes and exhibits anti-fibrotic activity in the lungs. Additionally, HDAC6-IN-44 has been shown to inhibit fibrosis progression in a bleomycin-induced mouse model and demonstrates good metabolic stability, making it a promising candidate for idiopathic pulmonary fibrosis research. |
| Targets&IC50 | HDAC4:847 nM, HDAC11:>5000 nM, HDAC2:3144 nM, HDAC1:878 nM, HDAC7:894 nM, HDAC10:1319 nM, HDAC6:8.97 nM |
| In vitro | HDAC6-IN-44 (compound H10), at concentrations of 2.5-10 μM and used over a duration of 1-300 μM for 48 hours, inhibits TGF-β-induced proliferation, cell viability, and HDAC6 activity in HELF cells in a dose-dependent manner, without causing significant cytotoxic effects. At 2.5-10 μM for 48 hours, HDAC6-IN-44 also interferes with TGF-β1-related fibrosis through modulation of HDAC6-related signaling pathways. |
| In vivo | The chemical compound HDAC6-IN-44 (compound H10), administered intraperitoneally at 0.1 mL/10g daily for three weeks, significantly suppresses the increase in HDAC6 activity and collagen deposition in the lung tissue of a pulmonary fibrosis mouse model. Additionally, HDAC6-IN-44 exhibits a dose-dependent inhibition of the progression of pulmonary fibrosis in this model.. |
| Formula | C20H21N3O3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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