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HDAC6-IN-44

🥰Excellent
Catalog No. T210360

HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC50 value of 8.97 nM. It can suppress idiopathic pulmonary fibrosis phenotypes and exhibits anti-fibrotic activity in the lungs. Additionally, HDAC6-IN-44 has been shown to inhibit fibrosis progression in a bleomycin-induced mouse model and demonstrates good metabolic stability, making it a promising candidate for idiopathic pulmonary fibrosis research.

HDAC6-IN-44

HDAC6-IN-44

🥰Excellent
Catalog No. T210360
HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC50 value of 8.97 nM. It can suppress idiopathic pulmonary fibrosis phenotypes and exhibits anti-fibrotic activity in the lungs. Additionally, HDAC6-IN-44 has been shown to inhibit fibrosis progression in a bleomycin-induced mouse model and demonstrates good metabolic stability, making it a promising candidate for idiopathic pulmonary fibrosis research.
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Product Introduction

Bioactivity
Description
HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC50 value of 8.97 nM. It can suppress idiopathic pulmonary fibrosis phenotypes and exhibits anti-fibrotic activity in the lungs. Additionally, HDAC6-IN-44 has been shown to inhibit fibrosis progression in a bleomycin-induced mouse model and demonstrates good metabolic stability, making it a promising candidate for idiopathic pulmonary fibrosis research.
Targets&IC50
HDAC4:847 nM, HDAC11:>5000 nM, HDAC2:3144 nM, HDAC1:878 nM, HDAC7:894 nM, HDAC10:1319 nM, HDAC6:8.97 nM
In vitro
HDAC6-IN-44 (compound H10), at concentrations of 2.5-10 μM and used over a duration of 1-300 μM for 48 hours, inhibits TGF-β-induced proliferation, cell viability, and HDAC6 activity in HELF cells in a dose-dependent manner, without causing significant cytotoxic effects. At 2.5-10 μM for 48 hours, HDAC6-IN-44 also interferes with TGF-β1-related fibrosis through modulation of HDAC6-related signaling pathways.
In vivo
The chemical compound HDAC6-IN-44 (compound H10), administered intraperitoneally at 0.1 mL/10g daily for three weeks, significantly suppresses the increase in HDAC6 activity and collagen deposition in the lung tissue of a pulmonary fibrosis mouse model. Additionally, HDAC6-IN-44 exhibits a dose-dependent inhibition of the progression of pulmonary fibrosis in this model..
Chemical Properties
FormulaC20H21N3O3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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