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G7-18NATE

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Catalog No. TP2579Cas No. 936728-13-1

G7-18NATE, a peptide inhibitor of Grb7, exhibits micromolar affinity (K D = 18.1 μM) for binding to the Grb7-SH2 domain. It effectively inhibits cell proliferation, motility, invasion, and 3D culture formation in various cancer cell lines [1] [2].

G7-18NATE
Other Forms of G7-18NATE:
G7-18NATE TFATP2787
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G7-18NATE

😃Good
Catalog No. TP2579Cas No. 936728-13-1
G7-18NATE, a peptide inhibitor of Grb7, exhibits micromolar affinity (K D = 18.1 μM) for binding to the Grb7-SH2 domain. It effectively inhibits cell proliferation, motility, invasion, and 3D culture formation in various cancer cell lines [1] [2].
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
G7-18NATE, a peptide inhibitor of Grb7, exhibits micromolar affinity (K D = 18.1 μM) for binding to the Grb7-SH2 domain. It effectively inhibits cell proliferation, motility, invasion, and 3D culture formation in various cancer cell lines [1] [2].
In vitro
G7-18NATE (10 μM, 24 h) inhibits the migration of MDA-MB-468 cells [2].
Chemical Properties
Molecular Weight1417.5
FormulaC67H80N14O19S
Cas No.936728-13-1
SmilesC(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC5=CC=C(O)C=C5)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N7[C@](C(=O)N[C@H](C(N)=O)CSCC(=O)N3)(CCC7)[H])[H]
Sequencecyclo(CH2CO-Trp-Phe-Glu-Gly-Tyr-Asp-Asn-Thr-Phe-Pro-Cys(NH2)-S-)
Sequence Shortcyclo(CH2CO-WFEGYDNTFP-Cys(NH2)-S-)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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