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Ladarixin

Name: Ladarixin
Brand: TargetMol
SKU: T32533
Price: 237 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T32533Cas No. 849776-05-2

Alias DF 2156A free base

Ladarixin (DF 2156A free base) is an orally active, non-competitive CXCR1/CXCR2 allosteric inhibitor that suppresses AKT, NF-κB, and angiogenesis, thereby slowing the progression of experimental human melanoma. It may be employed in research concerning COPD, asthma, and melanoma.

Ladarixin

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Purity: 99.36%

Catalog No. T32533Alias DF 2156A free baseCas No. 849776-05-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	-	In Stock
5 mg	$147	-	In Stock
10 mg	$237	-	In Stock
25 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$179	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.36%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ladarixin (DF 2156A free base) is an orally active, non-competitive CXCR1/CXCR2 allosteric inhibitor that suppresses AKT, NF-κB, and angiogenesis, thereby slowing the progression of experimental human melanoma. It may be employed in research concerning COPD, asthma, and melanoma.
In vitro	Ladarixin inhibits the migration of Homo sapiens polymorphonuclear leukocytes (PMNs) toward CXCL8, with a half-maximal inhibitory concentration (IC₅₀) of 0.7 nM [2].
In vivo	Ladarixin (10 mg/kg) administered orally demonstrated rapid onset of action (inhibiting early neutrophil infiltration 2 hours after a single dose), broad-spectrum anti-inflammatory effects (suppressing Th2/Th17 inflammation, fibrosis, and oxidative stress), and reversal of steroid resistance across various pulmonary disease models, with particularly notable potential in severe asthma and COPD exacerbation models [1]. When different Homo sapiens-derived melanoma cell lines were inoculated into NCrNU-M nude mice, Ladarixin (15 mg/kg) administered via intraperitoneal injection once daily significantly inhibited the growth of WM164, UM001, and UM004 melanomas, though it showed weaker inhibitory effects on C8161 melanoma growth. Ladarixin treatment markedly increased apoptotic areas and leukocyte infiltration in tumor tissues, particularly elevating the proportion of M1-type macrophages [2].
Synonyms	DF 2156A free base

Chemical Properties

Molecular Weight	375.34
Formula	C₁₁H₁₂F₃NO₆S₂
Cas No.	849776-05-2
Smiles	C[C@@H](C(=O)NS(C)(=O)=O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (213.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6643 mL	13.3213 mL	26.6425 mL	133.2126 mL
5 mM	0.5329 mL	2.6643 mL	5.3285 mL	26.6425 mL
10 mM	0.2664 mL	1.3321 mL	2.6643 mL	13.3213 mL
20 mM	0.1332 mL	0.6661 mL	1.3321 mL	6.6606 mL
50 mM	0.0533 mL	0.2664 mL	0.5329 mL	2.6643 mL
100 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3321 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc