Pip-alkyne-Ph-COOCH3

Name: Pip-alkyne-Ph-COOCH3
Brand: TargetMol
SKU: T18545
Rating: 4.5 (1 reviews)

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Catalog No. T18545Cas No. 2308496-47-9

Pip-alkyne-Ph-COOCH3 is an alkyl-chain based PROTAC linker used for synthesizing PROTAC ARD-266[1].

Pip-alkyne-Ph-COOCH3

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Catalog No. T18545Cas No. 2308496-47-9

Pip-alkyne-Ph-COOCH3 is an alkyl-chain based PROTAC linker used for synthesizing PROTAC ARD-266[1].

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500 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	Pip-alkyne-Ph-COOCH3 is an alkyl-chain based PROTAC linker used for synthesizing PROTAC ARD-266[1].
In vitro	ARD-266 is a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader[1].

Chemical Properties

Molecular Weight	243.3
Formula	C₁₅H₁₇NO₂
Cas No.	2308496-47-9
Relative Density.	1.13 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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