Namitecan

Name: Namitecan
Brand: TargetMol
SKU: T16268
Rating: 4.5 (1 reviews)

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Catalog No. T16268Cas No. 372105-27-6

Alias ST-1968

Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.

Namitecan

😃Good

Catalog No. T16268Alias ST-1968Cas No. 372105-27-6

Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,620	10-14 weeks	10-14 weeks
50 mg	$2,110	10-14 weeks	10-14 weeks
100 mg	$3,380	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.
In vitro	Namitecan decreases a dose-dependent decrease in EGFR expression in the different cell lines[1]. Namitecan and cetuximab cooperate in inhibiting EGFR expression. ST1968 causes a comparable level of apoptosis in A431 and A431/TPT cells (IC50: 0.21 and 0.29 μM)[2].
In vivo	Namitecan (10 mg/kg) combined with cetuximab (1 mg/mouse) demonstrates synergistic antitumor effects in SCC models, dependent on the EGFR gene copy number[1]. ST1968 (25 mg/kg) is associated with tolerable body weight loss and no fatal toxicity, achieving a 100% complete response rate in mice with the A431 tumor, and maintaining significant efficacy in topotecan-resistant tumors[2].
Synonyms	ST-1968

Chemical Properties

Molecular Weight	434.44
Formula	C₂₃H₂₂N₄O₅
Cas No.	372105-27-6
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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