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MKI-1

Name: MKI-1
Brand: TargetMol
SKU: T60688
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T60688Cas No. 1190277-80-5

Alias MASTL Kinase Inhibitor-1

MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cancer.

MKI-1

🥰Excellent

Purity: 99.69%

Catalog No. T60688Alias MASTL Kinase Inhibitor-1Cas No. 1190277-80-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	In Stock	In Stock
2 mg	$88	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$222	In Stock	In Stock
25 mg	$357	In Stock	In Stock
50 mg	$490	In Stock	In Stock
100 mg	$689	In Stock	In Stock
200 mg	$978	-	In Stock
1 mL x 10 mM (in DMSO)	$162	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.69%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cancer.
Targets&IC50	MASTL:9.9 μM
In vitro	MKI-1 (20 μM, 16 h) reduces c-Myc stability through PP2A activation in MCF7 cells. MKI-1 (5-20 μM) inhibits the activity of MASTL in breast cancer cells. MKI-1 (100 μM, 72 h) inhibits various oncogenic properties of breast cancer cells but showed much weaker effects on the viability of normal breast cells. MKI-1 clearly reduces both total c-Myc and serine 62-phosphorylation of c-Myc, with a decrease in ENSA phosphorylation[1].
In vivo	MKI-1 (50 mg/kg, ip, twice a week) enhances the radiosensitivity of the BT549 xenograft model to 6 Gy irradiation, reducing tumor growth without significant changes in body weight [1].
Synonyms	MASTL Kinase Inhibitor-1

Chemical Properties

Molecular Weight	302.33
Formula	C₁₈H₁₄N₄O
Cas No.	1190277-80-5
Smiles	O=C(Nc1nc2ccccc2[nH]1)c1cccc(c1)-n1cccc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (744.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3076 mL	16.5382 mL	33.0764 mL	165.3822 mL
5 mM	0.6615 mL	3.3076 mL	6.6153 mL	33.0764 mL
10 mM	0.3308 mL	1.6538 mL	3.3076 mL	16.5382 mL
20 mM	0.1654 mL	0.8269 mL	1.6538 mL	8.2691 mL
50 mM	0.0662 mL	0.3308 mL	0.6615 mL	3.3076 mL
100 mM	0.0331 mL	0.1654 mL	0.3308 mL	1.6538 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc