Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 80.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 318.00 | |
25 mg | In stock | $ 538.00 | |
50 mg | In stock | $ 872.00 | |
100 mg | In stock | $ 1,330.00 | |
500 mg | In stock | $ 2,660.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 217.00 |
Description | MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cancer. |
Targets&IC50 | MASTL:9.9 μM |
In vitro | MKI-1 (20 μM, 16 h) reduces c-Myc stability through PP2A activation in MCF7 cells. MKI-1 (5-20 μM) inhibits the activity of MASTL in breast cancer cells. MKI-1 (100 μM, 72 h) inhibits various oncogenic properties of breast cancer cells but showed much weaker effects on the viability of normal breast cells. MKI-1 clearly reduces both total c-Myc and serine 62-phosphorylation of c-Myc, with a decrease in ENSA phosphorylation[1]. |
In vivo | MKI-1 (50 mg/kg, ip, twice a week) enhances the radiosensitivity of BT549 xenograft model in response to 6 Gy irradiation (compared to the control) and reduces tumor growth with no notable changes in body weight[1]. |
Synonyms | MASTL Kinase Inhibitor-1 |
Molecular Weight | 302.33 |
Formula | C18H14N4O |
CAS No. | 1190277-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (744.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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MKI-1 1190277-80-5 Others MASTL Kinase Inhibitor-1 MKI 1 MKI1 inhibitor inhibit