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Chlormezanone

Name: Chlormezanone
Brand: TargetMol
SKU: T0715
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0715Cas No. 80-77-3

Alias Trancopal

Chlormezanone (Trancopal) is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.

Chlormezanone

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Purity: 99.89%

Catalog No. T0715Alias TrancopalCas No. 80-77-3

Chlormezanone (Trancopal) is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$40	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Chlormezanone AI Summary

Chlormezanone exhibits a diverse range of bioactivities and interactions. It shows potency in modulating Lamin A splicing, inhibiting interactions of thyroid hormone receptor and steroid receptor coregulator 2, and inducing erasure of genomic imprints. It is effective in inhibiting the proliferation of Plasmodium falciparum, modulating human peripheral myelin protein 22, and inhibiting several enzymes including human apurinic/apyrimidinic endonuclease 1, MPP8 chromodomain interactions, histone lysine methyltransferase G9a, mammalian selenoprotein thioredoxin reductase 1, and polymerase Iota. Additionally, it inhibits binding or entry into cells for Lassa virus and blocks entry of Ebola virus, while also enhancing Arylsulfatase A activity. The compound shows potential as an inhibitor of sodium fluorescein uptake in OATP1B3-transfected CHO cells and OATP1B1-transfected CHO cells, with high inhibition percentages of 92.0% and 97.47%, respectively. Chlormezanone demonstrates activity in the FDA HLAED assay related to liver enzyme composite activity and has been assessed for Drug Induced Liver Injury (DILI), being classified as DILI positive. It is associated with various forms of liver toxicity, including acute, cytolytic, and cholestatic liver toxicity, and severe hepatitis, but not with chronic liver diseases or liver tumors. Despite its broad range of bioactivities, Chlormezanone shows low bioactivity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2. It exhibits antiviral activity against SARS-CoV-2 with an IC50 value greater than 20,000 nM. Additionally, it slightly inhibits human HDAC6 enzyme activity and shows binding affinity towards several receptors such as ADRB2, OPRM1, and HRH2, though with no significant inhibitory effects on most targets at concentration levels tested. The compound's wide spectrum of interactions and bioactivities make it a compound of interest for further pharmacological investigation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chlormezanone (Trancopal) is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
Synonyms	Trancopal

Chemical Properties

Molecular Weight	273.74
Formula	C₁₁H₁₂ClNO₃S
Cas No.	80-77-3
Smiles	CN1C(c2ccc(Cl)cc2)S(=O)(=O)CCC1=O
Relative Density.	1.2205 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 6.8 mg/mL (24.84 mM), Sonication is recommended.

DMSO: 27.4 mg/mL (100.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6531 mL	18.2655 mL	36.5310 mL	182.6551 mL
5 mM	0.7306 mL	3.6531 mL	7.3062 mL	36.5310 mL
10 mM	0.3653 mL	1.8266 mL	3.6531 mL	18.2655 mL
20 mM	0.1827 mL	0.9133 mL	1.8266 mL	9.1328 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0731 mL	0.3653 mL	0.7306 mL	3.6531 mL
100 mM	0.0365 mL	0.1827 mL	0.3653 mL	1.8266 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc