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AS1708727

Name: AS1708727
Brand: TargetMol
SKU: T26661
Rating: 4.5 (1 reviews)

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Catalog No. T26661Cas No. 1253226-93-5

Alias AS-1708727, AS 1708727

AS1708727 is an orally bioavailable FOXO1 inhibitor that reduces plasma glucose and triglyceride levels in diabetic mice.

AS1708727

😃Good

Catalog No. T26661Alias AS-1708727, AS 1708727Cas No. 1253226-93-5

AS1708727 is an orally bioavailable FOXO1 inhibitor that reduces plasma glucose and triglyceride levels in diabetic mice.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$297	6-8 weeks	6-8 weeks
25 mg	$916	6-8 weeks	6-8 weeks
50 mg	$1,190	6-8 weeks	6-8 weeks
100 mg	$1,860	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	AS1708727 is an orally bioavailable FOXO1 inhibitor that reduces plasma glucose and triglyceride levels in diabetic mice.
In vitro	AS1708727 inhibits hepatic gluconeogenic gene expression and suppresses elevated blood glucose levels [1].
In vivo	AS1708727 (30-300 mg/kg; oral) reduces plasma glucose and triglyceride levels in diabetic db/db mice, exhibiting antidiabetic activity [1].
Synonyms	AS-1708727, AS 1708727

Chemical Properties

Molecular Weight	443.37
Formula	C₂₄H₂₄Cl₂N₂O₂
Cas No.	1253226-93-5
Smiles	O=C(N(C1=CC=C(Cl)C(=C1Cl)COC2=CC=CC=3C=NC=CC23)C)CC4CCCC4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (72.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2555 mL	11.2773 mL	22.5545 mL	112.7726 mL
5 mM	0.4511 mL	2.2555 mL	4.5109 mL	22.5545 mL
10 mM	0.2255 mL	1.1277 mL	2.2555 mL	11.2773 mL
20 mM	0.1128 mL	0.5639 mL	1.1277 mL	5.6386 mL
50 mM	0.0451 mL	0.2255 mL	0.4511 mL	2.2555 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

AS1708727

AS1708727

AS1708727

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Product Introduction

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In Vivo Formulation Calculator (Clear solution)

Dose Conversion

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Keywords