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AS1708727

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Catalog No. T26661Cas No. 1253226-93-5
Alias AS-1708727, AS 1708727

AS1708727 is an orally bioavailable FOXO1 inhibitor that reduces plasma glucose and triglyceride levels in diabetic mice.

AS1708727

AS1708727

😃Good
Catalog No. T26661Alias AS-1708727, AS 1708727Cas No. 1253226-93-5
AS1708727 is an orally bioavailable FOXO1 inhibitor that reduces plasma glucose and triglyceride levels in diabetic mice.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$2976-8 weeks6-8 weeks
25 mg$9166-8 weeks6-8 weeks
50 mg$1,1906-8 weeks6-8 weeks
100 mg$1,8606-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
AS1708727 is an orally bioavailable FOXO1 inhibitor that reduces plasma glucose and triglyceride levels in diabetic mice.
In vitro
AS1708727 inhibits hepatic gluconeogenic gene expression and suppresses elevated blood glucose levels [1].
In vivo
AS1708727 (30-300 mg/kg; oral) reduces plasma glucose and triglyceride levels in diabetic db/db mice, exhibiting antidiabetic activity [1].
SynonymsAS-1708727, AS 1708727
Chemical Properties
Molecular Weight443.37
FormulaC24H24Cl2N2O2
Cas No.1253226-93-5
SmilesO=C(N(C1=CC=C(Cl)C(=C1Cl)COC2=CC=CC=3C=NC=CC23)C)CC4CCCC4
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 32 mg/mL (72.17 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2555 mL11.2773 mL22.5545 mL112.7726 mL
5 mM0.4511 mL2.2555 mL4.5109 mL22.5545 mL
10 mM0.2255 mL1.1277 mL2.2555 mL11.2773 mL
20 mM0.1128 mL0.5639 mL1.1277 mL5.6386 mL
50 mM0.0451 mL0.2255 mL0.4511 mL2.2555 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

AS1708727
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