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BRD0209
🥰Excellent
Catalog No. T26894Cas No. 1597439-87-6
Alias BRD-0209, BRD 0209
BRD0209 is a highly selective and potent GSK3 inhibitor.
BRD0209
🥰Excellent
Purity: 99.92%
Catalog No. T26894Alias BRD-0209, BRD 0209Cas No. 1597439-87-6
BRD0209 is a highly selective and potent GSK3 inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $32 | In Stock | |
| 5 mg | $54 | In Stock | |
| 10 mg | $88 | In Stock | |
| 25 mg | $158 | In Stock |
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Purity:99.92%
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Product Introduction
Bioactivity
Chemical Properties
| Description | BRD0209 is a highly selective and potent GSK3 inhibitor. |
| Targets&IC50 | GSK-3α:19 nM, GSK-3β:5 nM |
| In vitro | BRD0209 showed concentration-dependent inhibition of Tau with cellular EC50s of 1.76 μM, respectively, in SH-SY5Y cells using ELISA. Treatment of SH-SY5Y cells with BRD0209 (10 μM) significantly inhibited GSK3 kinase activity within 30 min, as seen in the decrease in phospho-CRMP2 and phospho-β-catenin. BRD0209 is also a reversible ATP-competitive inhibitor with fast-off kinetics (Ki = 4.2 nM, respectively).BRD0209 treatment caused a dramatic decrease in autophosphorylation at Tyr279 (pGSK3α) and Tyr216 (pGSK3β) with longer exposure (24 h) [1]. |
| Synonyms | BRD-0209, BRD 0209 |
| Molecular Weight | 347.45 |
| Formula | C22H25N3O |
| Cas No. | 1597439-87-6 |
| Smiles | C[C@@]1(C2=C(NN=C2NC3=C1C(=O)CC(C)(C)C3)C4CC4)C5=CC=CC=C5 |
| Relative Density. | 1.31g/cm3 |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.47 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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