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PROTAC SMARCA2/4-degrader-22
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Catalog No. T200581Cas No. 2568277-48-3
SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting both SMARCA2 and SMARCA4. In A549 cells, it achieves degradation of SMARCA2/4 proteins with DC50s less than 100 nM and a maximal degradation rate (Dmax%) exceeding 90% after a 24-hour treatment.
PROTAC SMARCA2/4-degrader-22
😃Good
Catalog No. T200581Cas No. 2568277-48-3
SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting both SMARCA2 and SMARCA4. In A549 cells, it achieves degradation of SMARCA2/4 proteins with DC50s less than 100 nM and a maximal degradation rate (Dmax%) exceeding 90% after a 24-hour treatment.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting both SMARCA2 and SMARCA4. In A549 cells, it achieves degradation of SMARCA2/4 proteins with DC50s less than 100 nM and a maximal degradation rate (Dmax%) exceeding 90% after a 24-hour treatment. |
| Molecular Weight | 956.17 |
| Formula | C51H61N11O6S |
| Cas No. | 2568277-48-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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