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Anti-MSH6 Antibody (5V942)
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Catalog No. TMAH-00785
Alias Sperm associated protein, p160, MutS-alpha 160 kDa subunit, mutS homolog 6, MutS alpha 160 kDa subunit, mutS (E. coli) homolog 6, MSH 6, HSAP, HNPCC5, HNPCC 5, hMSH6, GTMBP, GTBP, G/T mismatch binding protein, DNA mismatch repair protein Msh6
Anti-MSH6 Antibody (5V942) is a Mouse antibody targeting MSH6. Anti-MSH6 Antibody (5V942) can be used in ELISA, IHC.
Anti-MSH6 Antibody (5V942)
Anti-MSH6 Antibody (5V942)
😃Good
Catalog No. TMAH-00785Alias Sperm associated protein, p160, MutS-alpha 160 kDa subunit, mutS homolog 6, MutS alpha 160 kDa subunit, mutS (E. coli) homolog 6, MSH 6, HSAP, HNPCC5, HNPCC 5, hMSH6, GTMBP, GTBP, G/T mismatch binding protein, DNA mismatch repair protein Msh6
Anti-MSH6 Antibody (5V942) is a Mouse antibody targeting MSH6. Anti-MSH6 Antibody (5V942) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μg | $207 | 7-10 days | |
| 100 μg | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-MSH6 Antibody (5V942) is a Mouse antibody targeting MSH6. Anti-MSH6 Antibody (5V942) can be used in ELISA, IHC. |
| Alias | Sperm associated protein, p160, MutS-alpha 160 kDa subunit, mutS homolog 6, MutS alpha 160 kDa subunit, mutS (E. coli) homolog 6, MSH 6, HSAP, HNPCC5, HNPCC 5, hMSH6, GTMBP, GTBP, G/T mismatch binding protein, DNA mismatch repair protein Msh6 |
| Ig Type | IgG |
| Clone | 5V942 |
| Reactivity | Human |
| Verified Activity | Immunohistochemical of paraffin-embedded Human lung cancer tissue using TMAH-00785 at dilution of 1:200. |
| Application | ELISA, IHC |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Nucleus. Chromosome. Note=Associates with H3K36me3 via its PWWP domain. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Purity | >95% |
| Research Background | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human MSH6 Protein |
| Antigen Species | Human |
| Gene ID | 2956 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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