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Idactamab
🥰Excellent
Catalog No. T77385Cas No. 2245205-37-0
Alias INT-001
Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2. Idactamab can be used to prepare ADC MEDI7247.
Idactamab
Idactamab
🥰Excellent
Catalog No. T77385Alias INT-001Cas No. 2245205-37-0
Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2. Idactamab can be used to prepare ADC MEDI7247.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $297 | In Stock | |
| 5 mg | $788 | In Stock | |
| 10 mg | $1,230 | In Stock |
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Concentration:4.32 mg/mL
Purity:> 95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2. Idactamab can be used to prepare ADC MEDI7247. |
| Targets&IC50 | Hematologic cancer cells:0.05-65 ng/mL |
| In vitro | Idactamab exhibits inhibitory effects on various hematologic cancer cell lines, with an IC50 ranging from 0.05 to 65 ng/mL [2].
ASCT2 (SLC1A5) is a multi-channel, Na+-dependent neutral amino acid transporter that mediates the uptake of amino acids required for tumor growth and progression [2]. |
| In vivo | Idactamab enhances the survival rates of three disseminated acute myeloid leukemia (AML) cell line models: TF1α (high expression of ASCT2), MOLM-13 (low expression of ASCT2), and M.V.411 (high expression of ASCT2). The corresponding minimum inhibitory concentrations are 0.05 mg/kg, 0.1 mg/kg, and 0.1 mg/kg, respectively [1]. |
| Synonyms | INT-001 |
| Molecular Weight | 146.2 kDa |
| Cas No. | 2245205-37-0 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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