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Idactamab (Synonyms: INT-001)
Catalog No. T77385 Copy Product Info
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Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2. Idactamab can be used to prepare ADC MEDI7247.
Idactamab
Copy Product Info🥰Excellent
Catalog No. T77385
Synonyms INT-001
Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2. Idactamab can be used to prepare ADC MEDI7247.
Idactamab
Cas No. 2245205-37-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $228 | - | In Stock | |
| 5 mg | $745 | - | In Stock | |
| 10 mg | $1,180 | - | In Stock | |
| 25 mg | $1,390 | - | In Stock | |
| 50 mg | $1,870 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 95%
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2. Idactamab can be used to prepare ADC MEDI7247. |
| Targets&IC50 | Hematologic cancer cells:0.05-65 ng/mL |
| In vitro | Idactamab exhibits inhibitory effects on various hematologic cancer cell lines, with an IC50 ranging from 0.05 to 65 ng/mL [2].
ASCT2 (SLC1A5) is a multi-channel, Na+-dependent neutral amino acid transporter that mediates the uptake of amino acids required for tumor growth and progression [2]. |
| In vivo | Idactamab enhances the survival rates of three disseminated acute myeloid leukemia (AML) cell line models: TF1α (high expression of ASCT2), MOLM-13 (low expression of ASCT2), and M.V.411 (high expression of ASCT2). The corresponding minimum inhibitory concentrations are 0.05 mg/kg, 0.1 mg/kg, and 0.1 mg/kg, respectively [1]. |
| Synonyms | INT-001 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | SLC1A5/AAAT/ASCT2/M7V1/RDR/RDRC |
| Molecular Weight | 146.2 kDa |
| Cas No. | 2245205-37-0 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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