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TBA-7371

Name: TBA-7371
Brand: TargetMol
SKU: T3224
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3224Cas No. 1494675-86-3

Alias DprE1-IN-1, AZ 7371

TBA-7371 (DprE1-IN-1) is a potent inhibitor of DprE1 and PDE6.

TBA-7371

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Purity: 99.54%

Catalog No. T3224Alias DprE1-IN-1, AZ 7371Cas No. 1494675-86-3

TBA-7371 (DprE1-IN-1) is a potent inhibitor of DprE1 and PDE6.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	In Stock	In Stock
25 mg	$76	In Stock	In Stock
50 mg	$123	In Stock	In Stock
100 mg	$211	In Stock	In Stock
200 mg	$313	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.54%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

TBA-7371 AI Summary

TBA-7371 demonstrates significant antimycobacterial and antibacterial activities, particularly against Mycobacterium tuberculosis, with MIC values ranging from 390 nM to over 200 µM. It also shows strong inhibitory activity against Mycobacterium smegmatis thioredoxin with IC50 values in the single-digit nanomolar range. The compound exhibits moderate permeability across Caco-2 cells and has favorable pharmacokinetic properties such as high kinetic solubility in phosphate buffer at pH 7.4, a logD value of 1.8, and a protein binding fraction of 0.22 in human plasma. Additionally, it maintains good oral bioavailability in rats and is non-cytotoxic against human A549 cells at concentrations above 100 µM. The compound also displays moderate inhibition of human ERG and various cytochrome P450 enzymes at concentrations above 33 µM or 50 µM and demonstrates a reduction in Mycobacterium tuberculosis CFU in a Wistar rat model at an oral dose of 100 mg/kg..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	TBA-7371 (DprE1-IN-1) is a potent inhibitor of DprE1 and PDE6.
Targets&IC50	PDE6:6 μM, DprE1:10 nM
Synonyms	DprE1-IN-1, AZ 7371

Chemical Properties

Molecular Weight	355.39
Formula	C₁₈H₂₁N₅O₃
Cas No.	1494675-86-3
Smiles	COc1ncnc(Cn2cc(C(=O)NCCO)c3ncc(C)cc23)c1C
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.11 mg/mL (17.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8138 mL	14.0691 mL	28.1381 mL	140.6905 mL
5 mM	0.5628 mL	2.8138 mL	5.6276 mL	28.1381 mL
10 mM	0.2814 mL	1.4069 mL	2.8138 mL	14.0691 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc